Results 141 to 150 of about 299,721 (404)

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Seasonal changes in antioxidative/oxidative profile of mining and non-mining populations of Syrian beancaper as determined by soil conditions [PDF]

, 2017
Soil pollution by heavy metals/metalloids (HMMs) is a problem worldwide. To prevent dispersion of contaminated particles by erosion, the maintenance of a vegetative cover is needed.
Bueso Sánchez, María del Carmen, Calderón García, Antonio Asensio, Conesa Alcaraz, Héctor Miguel, Ferrer Ayala, María Ángeles, López Orenes, Antonio   +4 more
core   +2 more sources

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases*♦

Journal of Biological Chemistry, 2009
H2O2 acts as a signaling molecule by oxidizing critical thiol groups on redox-regulated target proteins. To explain the efficiency and selectivity of H2O2-based signaling, it has been proposed that oxidation of target proteins may be facilitated by H2O2 ...
M. Gutscher, Mirko C. Sobotta, G. Wabnitz, S. Ballikaya, A. J. Meyer, Y. Samstag, T. Dick   +6 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

ATIVIDADE DE PEROXIDASES (EC 1.11.1.7) E TEOR DE PROLINA NO EMBRIÃO E COTILÉDONES DE FEIJOEIRO Phaseolus vulgaris L. EM CONDIÇÕES DE SALINIDADE

Scientia Agricola, 1997
Os efeitos da salinidade sobre a atividade de peroxidases foram acompanhadas no embrião e em cotilédones de feijoeiro Phaseolus vulgaris L. cv. Carioca, observando-se em ambos, aumento na atividade das enzimas.
G.P.P. LIMA, C. ROSSI, D.M.R. HAKVOORT
doaj   +1 more source

Identification of markers associated with bacterial blight resistance loci in cowpea (Vigna unguiculata (L.) Walp.) [PDF]

, 2010
Cowpea bacterial blight (CoBB), caused by Xanthomonas axonopodis pv. vignicola (Xav), is a worldwide major disease of cowpea [Vigna unguiculata (L.) Walp.].
Agbicodo, A.C.M.E., Bandyopadhyay, R., Close, T.J., Diop, N.N., Ehlers, J.D., Fatokun, C.A., Linden, C.G., van der, Muchero, W., Roberts, P.A., Visser, R.G.F., Wydra, K.   +10 more
core   +2 more sources

PeroxiBase: a database for large-scale evolutionary analysis of peroxidases

Nucleic Acids Res., 2012
The PeroxiBase (http://peroxibase.toulouse.inra.fr/) is a specialized database devoted to peroxidases’ families, which are major actors of stress responses.
Nizar Fawal, Qiang Li, B. Savelli, M. Brette, G. Passaia, Maxime Fabre, Catherine Mathé, C. Dunand   +7 more
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Peroxidase expression in a cereal cyst nematode (Heterodera avenae) resistant hexaploid wheat line.

, 2008
The incompatible interaction between plant and pathogen is often determined by the hypersensitive reaction (HR). This response is associated with accumulation of reactive oxygen species (ROS), which results in adverse growth conditions for pathogens. Two
Andrés, María Fe, Briceño-Félix, G., Delibes Castro, Angeles, Lopez Braña, Isidoro, Martín-Sánchez, J.A., Martínez García, Chelo, Michelena, A., Moreno Vazquez, Santiago, Romero, M.D., Simonetti, Ester, Sin, E., Torres, L.   +11 more
core  

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source