Results 161 to 170 of about 53,020 (303)

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide

Hydrogen peroxide is thought to regulate cellular processes by direct oxidation of numerous cellular proteins, whereas antioxidants, most notably thiol peroxidases, are thought to reduce peroxides and inhibit H2O2 response.
Fomenko DE, Agisheva N, Koc A, Jacobsen M, Kaya A, Rutherford JC, Jin DY, Gladyshev VN, Winge DR, Malinouski M, Siu KL   +10 more
core   +2 more sources

Plant Biomass Depolymerization by Oxidoreductases: Structural Characteristics, Synergy Mechanism, and Evolutionary Adaptation. [PDF]

J Agric Food Chem
Ma X, Csarman F, Guan Y, Wang L, Ludwig R, Ma S.   +5 more
europepmc   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

Biodegradation of Polyvinyl Chloride by <i>Acinetobacter</i> sp. Isolated from Soil. [PDF]

Microorganisms
Chai S, Wang J, Zhang Y, Zhang Z, Yang Z, Wei Y, Niu M.   +6 more
europepmc   +1 more source

Low‐Intensity Focused Ultrasound Enables Temporal Modulation of Human Midbrain Organoid Differentiation

Advanced Science, EarlyView.
In this study, we demonstrate that low‐intensity ultrasound stimulation enables temporal modulation of midbrain organoid differentiation using a modular multi‐well stimulation platform. In particular, we show that ultrasound promotes the proliferation of dopaminergic progenitor cells.
Jinseong Jeong, Yehhyun Jo, Youngsun Lee, Eunyoung Jang, Yeonji Jeong, Won Do Heo, Jennifer H. Shin, Mi‐Ok Lee, Hyunjoo J. Lee   +8 more
wiley   +1 more source

Deciphering Interheme Electron-Transfer Pathways in a Diheme Peroxidase from Methane-Oxidizing Bacteria. [PDF]

J Am Chem Soc
Stein RE, Manesis AC.
europepmc   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Prospecting Ligninolytic Enzymes Toward Lignin Valorization

BioResources
The enzymatic breakdown of lignin generates a spectrum of aromatic monomers — including vanillin, guaiacol, syringaldehyde, vanillic acid, ferulic acid, and p-coumaric acid — that serve as platform chemicals for pharmaceuticals, fragrances, resins, and ...
Bo-Chao Gao, Eric Fordjour, Jian-Ning Hu, Tao Xu, Xia Li, Zhi-Hua Liu, Bing-Zhi Li   +6 more
doaj  

Development and optimization of a glycerol-based fed-batch strategy for the production of peroxidases with Komagataella phaffii under the P_DF promoter. [PDF]

Microb Cell Fact
Wagner CM, Schwartz K, Czech H, Lamping I, Garcia-Ortega X, Glieder A, Wiechert W, Oldiges M.   +7 more
europepmc   +1 more source