Results 31 to 40 of about 90,192 (259)

Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis

BMC Gastroenterology, 2005
Background Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of nonalcoholic steatohepatitis.
Sarifakiogullari Serpil, Aslan Mehmet, Sabuncu Tevfik, Bolukbas Fusun F, Bolukbas Cengiz, Horoz Mehmet, Gunaydin Necla, Erel Ozcan   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Shelf Life and Functional Quality of Almond Bagasse Powders as Influenced by Dehydration and Storing Conditions

Foods
Almond bagasse resulting after the production of almond-based drinks represents a promising by-product with potential for use as a functional ingredient.
Stevens Duarte, Ester Betoret, Noelia Betoret   +2 more
doaj   +1 more source

Prediction of whiteness index of cotton using bleaching process variables by fuzzy inference system

Fashion and Textiles, 2018
A fuzzy prediction model has been built based on hydrogen peroxide concentration, temperature and time of bleaching as the input variables and knitted fabric whiteness index as the output variable.
Abu Naser Md. Ahsanul Haque, Shamima Akter Smriti, Manwar Hussain, Nawshin Farzana, Fahmida Siddiqa, Md. Azharul Islam   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

QUALITY ASSESSMENT OF HANDMADE SOAPS, PLANT-BASED OILS, AND SKINCARE CREAMS: PHYSICOCHEMICAL AND MICROBIOLOGICAL ANALYSIS

Studia Universitatis Babes-Bolyai Chemia
The aim of this study was to evaluate the quality and safety of handmade cosmetic and hygiene products through physicochemical and microbiological determinations, prior to their placement on the market.
Ana BALEA, Irina CIOTLĂUȘ, Rahela CARPA, Mihaela-Cecilia VLASSA, Sonia ANDRESI   +4 more
doaj   +1 more source

Improved Strength of Peroxide-Bleached Deinked Pulp after TEMPO-Mediated Oxidation at Medium Consistency

BioResources, 2015
Deinked pulp was pretreated using the 4-acetamido-2,2,6,6,- tetramethyl-pipelidine-1-oxyl radical (TEMPO)/NaBr/NaClO system and then bleached using hydrogen peroxide to achieve a medium pulp consistency. The effect of the amount of oxidant NaClO addition
Feiguo Hua, Shuhua Tong, Rendang Yang, Bin Wang, Fei Yang   +4 more
doaj   +1 more source