Results 41 to 50 of about 3,856,820 (291)

Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis

BMC Gastroenterology, 2005
Background Oxidative stress, an increase in oxidants and/or a decrease in antioxidant capacity, is one of the potential biochemical mechanisms involved in the pathogenesis of nonalcoholic steatohepatitis.
Sarifakiogullari Serpil, Aslan Mehmet, Sabuncu Tevfik, Bolukbas Fusun F, Bolukbas Cengiz, Horoz Mehmet, Gunaydin Necla, Erel Ozcan   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Shelf Life and Functional Quality of Almond Bagasse Powders as Influenced by Dehydration and Storing Conditions

Foods
Almond bagasse resulting after the production of almond-based drinks represents a promising by-product with potential for use as a functional ingredient.
Stevens Duarte, Ester Betoret, Noelia Betoret   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Prediction of whiteness index of cotton using bleaching process variables by fuzzy inference system

Fashion and Textiles, 2018
A fuzzy prediction model has been built based on hydrogen peroxide concentration, temperature and time of bleaching as the input variables and knitted fabric whiteness index as the output variable.
Abu Naser Md. Ahsanul Haque, Shamima Akter Smriti, Manwar Hussain, Nawshin Farzana, Fahmida Siddiqa, Md. Azharul Islam   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

QUALITY ASSESSMENT OF HANDMADE SOAPS, PLANT-BASED OILS, AND SKINCARE CREAMS: PHYSICOCHEMICAL AND MICROBIOLOGICAL ANALYSIS

Studia Universitatis Babes-Bolyai Chemia
The aim of this study was to evaluate the quality and safety of handmade cosmetic and hygiene products through physicochemical and microbiological determinations, prior to their placement on the market.
Ana BALEA, Irina CIOTLĂUȘ, Rahela CARPA, Mihaela-Cecilia VLASSA, Sonia ANDRESI   +4 more
doaj   +1 more source

Time-resolved quantitative assays and imaging of enzymes and enzyme substrates using a new europium fluorescent probe for hydrogen peroxide [PDF]

, 2005
The thesis describes the development of a novel reversible H2O2 fluorescent probe comprising the ternary complex of europium(III), tetracycline and hydrogen peroxide; and its application in the assays of H2O2, of H2O2 producing oxidases and their ...
Wu, Meng
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source