Results 81 to 90 of about 202,217 (306)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Study of Chemical Composition and Evaluation of Anti-hypertensive Effect of A Fixed Oil Extracted from Linum usitatissimum grains

Journal of Food and Pharmaceutical Sciences
Globally grown flax seed is regarded as an oilseed with numerous medicinal and health are the outcomes of the physico-chemical analyses: pH value: 0.476; saponification index: 168.3; KOH/g: 28.05; peroxide index: 174; density: 0.951; refractive index: 1 ...
Oulad Ali Halima, Mebarka, Nasser Belboukhari, Khaled Sekkoum, Khawter   +4 more
doaj   +1 more source

Depended pH behavior of chitosan on surface modified fibers of Kraft pulp [PDF]

تحقیقات علوم چوب و کاغذ ایران, 2015
Chitosan is known as a natural polymer which improves strengths of papers. So, in this study investigated improvement of chitosan absorption on modified craft fibers and increase its efficiency.
Noraldin Nazarnezhad, Naser Rasol pour hedayati, Omid Ramazani   +2 more
doaj   +1 more source

The oxidation stability of extra virgin avocado oil : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Food Science at Massey University [PDF]

, 2002
Extra virgin avocado oil (EVAO) is extracted from avocado fruit with minimal processing. It contains a wide range of non-lipid compounds that have a profound affect on oil stability.
Sherpa, Nimma
core  

Effects of organic plant oils and role of oxidation on nutrient utilization in juvenile rainbow trout (Oncorhynchus mykiss) [PDF]

, 2012
The study compared the effect of four either fresh or force oxidized organic plant oils in diets for juvenile rainbow trout (Oncorhynchus mykiss) in which 47% of conventional LT fish meal protein was substituted by a mixture of 3 organic plant protein ...
A. Jokumsen, Bell, Bligh, Bransden, Børsting, C. Jacobsen, Caballero, Dalsgaard, Fountoulaki, Geurden, Geurden, I. Lund, J. Dalsgaard, J. Holm, J.H. Hansen, Jobling, Kaitaranta, Kasumyan, Kolar, Koshio, Laohabanjong, Lund, Lund, Lutterodt, Menoyo, Mente, Ng, Peng, Petersen, Petterson, Pickova, Ping, Shahidi, Shantha, Singh, Sun-Waterhouse, Takeda, Tyl   +37 more
core   +1 more source

Effect of ethanol and iron on the hepatic and biliary levels of glutathione and lipid peroxidative indexes

Alcohol, 1985
Data presented here indicate that iron exposure exacerbates the changes in the glutathione status of the liver cell and the lipid peroxidative response of the tissue induced by acute ethanol intoxication. In these conditions, additivity in lipid peroxidation was found to occur either when the process was estimated by hepatic malondialdehyde formation ...
Videla Cabrera, Luis, Fernández Arancibia, Virginia, Valenzuela Bonomo, Carlos   +2 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Morphological and Behavioral Abnormalities Induced by Hydrogen Peroxide in Drosophila melanogaster

Biology
Congenital developmental defects are among the postnatal consequences of early exposure to hydrogen peroxide or other teratogens that induce oxidative stress, highlighting a potential mechanistic link between oxidative stress, redox signaling, and ...
María Llasbeth Hernández-Calderón, Alondra Gallegos-Moreno, Aneet Yamely Miranda-Camacho, Claudia Linette Sánchez-Jiménez, Sandra Díaz-Barriga-Arceo, Jorge Alejandro Aguirre-Joya, Cristian Torres-León, David Ramiro Aguillón-Gutiérrez   +7 more
doaj   +1 more source