Results 231 to 240 of about 19,535 (281)
Beyond ROS clearance: Peroxiredoxins in stress signaling and aging.
Ageing Research Reviews, 2018 Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in ...
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The biological role of peroxiredoxins in innate immune responses of aquatic invertebrates
Fish and Shellfish Immunology, 2019Peroxiredoxins (Prxs) are a widespread and greatly transcribed family of antioxidant proteins, which rapidly detoxify peroxynitrite, hydrogen peroxide and organic hydroperoxides.
Muhammad Nadeem Abbas +2 more
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Relevance of peroxiredoxins in pathogenic microorganisms
Applied Microbiology and Biotechnology, 2021 : The oxidative and nitrosative responses generated by animals and plants are important defenses against infection and establishment of pathogenic microorganisms such as bacteria, fungi, and protozoa.
M. A. de Oliveira +7 more
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Biological Chemistry, 2002
Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic principles, specificities and biological function. Peroxiredoxins are low efficiency peroxidases using thiols as reductants. They appear to be fairly promiscuous with respect to the hydroperoxide substrate; the specificities for the donor substrate vary considerably ...
Birgit, Hofmann +2 more
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Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic principles, specificities and biological function. Peroxiredoxins are low efficiency peroxidases using thiols as reductants. They appear to be fairly promiscuous with respect to the hydroperoxide substrate; the specificities for the donor substrate vary considerably ...
Birgit, Hofmann +2 more
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Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI
2007All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxin (Prx) VI is the isoform expressed at the highest level and its lung expression exceeds that for other organs. The predominant location of Prx VI is the cytosol and acidic organelles of Clara cells of the conducting airways and type II epithelial cells and macrophages in the ...
Bruno, Schremmer +3 more
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Targeting peroxiredoxins against leukemia
Experimental Cell Research, 2013Peroxiredoxins (Prx), a family of small non-seleno peroxidases, are important regulators for cellular reactive oxygen species (ROS), which contribute to many signaling pathways and pathogenesis of diseases. Targeting redox homeostasis is being developed as a promising therapeutic strategy for many diseases such as cancers.
Chuan-Xu Liu +2 more
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2019
In the present study we describe the molecular characterization of the two paralogous mitochondrial peroxiredoxins from Trematomus bernacchii, a teleost that plays a pivotal role in the Antarctic food chain.
A. M. Tolomeo +9 more
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In the present study we describe the molecular characterization of the two paralogous mitochondrial peroxiredoxins from Trematomus bernacchii, a teleost that plays a pivotal role in the Antarctic food chain.
A. M. Tolomeo +9 more
semanticscholar +1 more source
2007
Some members of the Prx family are up-regulated in cells under stress conditions. Prx I is the major cytoplasmic Prx and is known as a stress-inducible antioxidant enzyme. Various stress agents or conditions activate Prx I gene expression in vitro and in vivo.
Tetsuro, Ishii, Toru, Yanagawa
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Some members of the Prx family are up-regulated in cells under stress conditions. Prx I is the major cytoplasmic Prx and is known as a stress-inducible antioxidant enzyme. Various stress agents or conditions activate Prx I gene expression in vitro and in vivo.
Tetsuro, Ishii, Toru, Yanagawa
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Structural Survey of the Peroxiredoxins
2007Peroxiredoxins (Prxs) are ubiquitous proteins that use an active site Cys residue to reduce hydroperoxides. Structural studies since the first Prx structure was determined in 1998 have produced 35 crystal structures of wild type and mutant Prxs with at least one representative structure from each of the five major evolutionary subfamilies of Prxs ...
P Andrew, Karplus, Andrea, Hall
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The Catalytic Mechanism of Peroxiredoxins
2007Peroxiredoxins carry out the efficient reduction of a typically broad range of peroxide substrates through an absolutely conserved, activated cysteine residue within a highly conserved active site pocket structure. Though details of reductive recycling after cysteine sulfenic acid formation at the active site vary among members of different Prx classes,
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