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Enhanced hyperoxidation of peroxiredoxin 2 and peroxiredoxin 3 in the presence of bicarbonate/CO2
Free Radical Biology and Medicine, 2019Hydrogen peroxide undergoes an equilibrium reaction with bicarbonate/CO2 to produce peroxymonocarbonate (HCO4-). Peroxymonocarbonate is more reactive with thiols than H2O2 but it makes up only a small fraction of the H2O2 in physiological bicarbonate buffers so the increase in rate of oxidation of low molecular weight thiols is modest.
Alexander V, Peskin +2 more
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2000
Abstract The peroxiredoxin family is a widely distributed class of enzymes that directly reduce H2O2 and other hydroperoxides, with hydrogen derived from NAD(P)H, by different routes (1). Two highly conserved cysteine residues are revealed by alignment of the peroxiredoxin family members.
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Abstract The peroxiredoxin family is a widely distributed class of enzymes that directly reduce H2O2 and other hydroperoxides, with hydrogen derived from NAD(P)H, by different routes (1). Two highly conserved cysteine residues are revealed by alignment of the peroxiredoxin family members.
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Peroxiredoxins as biomarkers of oxidative stress
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014Peroxiredoxins (Prxs) are a class of abundant thiol peroxidases that degrade hydroperoxides to water. Prxs are sensitive to oxidation, and it is hypothesized that they also act as redox sensors. The accumulation of oxidized Prxs may indicate disruption of cellular redox homeostasis.This review discusses the biochemical properties of the Prxs that make ...
Rebecca A, Poynton, Mark B, Hampton
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Peroxiredoxin 6 is a natural radioprotector
Doklady Biochemistry and Biophysics, 2016After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and ...
M G, Sharapov +8 more
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Peroxiredoxin Systems in Mycobacteria
2007Like other actinomycetes Mycobacterium tuberculosis lacks glutathione and, consequently, the glutathione peroxidases that dominate the antioxidant defence of its mammalian hosts. The hydrogen peroxide metabolism of the pathogen has for long been recognised to depend on a heme-containing catalase/peroxidase.
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Role of Glutathione Peroxidases and Peroxiredoxins in Free Radical-Induced Pathologies
Biochemistry (Moscow), 2021M. Sharapov +3 more
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Structure, mechanism and regulation of peroxiredoxins.
TIBS -Trends in Biochemical Sciences. Regular ed, 2003Z. A. Wood +3 more
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Sub-cellular biochemistry, 2008
Mitochondria are the major intracellular sites of oxygen consumption producing reactive oxygen species (ROS) as toxic by-products of oxidative phosphorylation, primarily via electron leakage from the respiratory chain. The resultant types of chemical damage to lipids, DNA and proteins are described as well as the broader implications for the ...
Zhenbo, Cao +2 more
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Mitochondria are the major intracellular sites of oxygen consumption producing reactive oxygen species (ROS) as toxic by-products of oxidative phosphorylation, primarily via electron leakage from the respiratory chain. The resultant types of chemical damage to lipids, DNA and proteins are described as well as the broader implications for the ...
Zhenbo, Cao +2 more
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Peroxiredoxins couple metabolism and cell division in an ultradian cycle
Nature Chemical Biology, 2021P. S. Amponsah +7 more
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Evolution of the peroxiredoxins.
Sub-cellular biochemistry, 2008Peroxiredoxins compose a superfamily of peroxidases ubiquitously found throughout evolution in prokaryotes, archaea and eukaryotes. These enzymes contain a conserved catalytic peroxidatic cysteine (Cp) in the N-terminal region of the protein. The residues surrounding Cp and the catalytic site appear also to be well conserved.
Bernard, Knoops +2 more
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