Results 91 to 100 of about 261,210 (338)

Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Advanced Science, EarlyView.
Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang   +9 more
wiley   +1 more source

The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]

, 2019
Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel, Ermatov, Nurmukambed, Konger, Raymond L., Ren, Lu, Sahu, Ravi P.   +4 more
core   +1 more source

Peroxisome Deficiency Dysregulates Fatty Acid Oxidization and Exacerbates Lipotoxicity in β Cells [PDF]

, 2021
Hong-Bo Guan, Yanyan Guo, Liangliang Zhu, Yisheng Jiao, Xiaomei Liu   +4 more
openalex   +1 more source

Peroxisome Biogenesis Disorders

Translational Science of Rare Diseases, 2016
The peroxisome biogenesis disorders (PBD) are a heterogeneous group of autosomal recessive disorders in which peroxisome assembly is impaired, leading to deficiencies of peroxisomal enzymes, complex developmental sequelae and progressive disabilities.
Argyriou, Catherine, D’Agostino, Maria Daniela, Braverman, Nancy   +2 more
openaire   +3 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. [PDF]

, 2007
Peroxisome proliferator-activated receptor (PPAR)alpha is a nuclear receptor that mediates gender differences in lipid metabolism. PPARalpha also functions to control inflammatory responses by repressing the activity of nuclear factor kappaB (NF-kappaB ...
Baranzini, Sergio E, Crowell, Andrea, Dunn, Shannon E, Loh, John, Oksenberg, Jorge, Ousman, Shalina S, Sobel, Raymond A, Steinman, Lawrence, Youssef, Sawsan, Zuniga, Luis   +9 more
core  

Pioglitazone Prevents Capillary Rarefaction in Streptozotocin-Diabetic Rats Independently of Glucose Control and Vascular Endothelial Growth Factor Expression [PDF]

, 2012
Background/Aims: Reduction of capillary network density occurs early in the development of metabolic syndrome and may be relevant for the precipitation of diabetes.
Andreas Dendorfer, Arany Z, Astrid Ashoff, Baraka A, Battegay EJ, Billiet L, Biscetti F, Blasi ER, Chintalgattu V, Cipolla MJ, Dendorfer A, Duan SZ, Emanueli C, Emoto M, Fatimunnisa Qadri, Frisbee JC, Frisbee JC, Frisbee JC, Gealekman O, Geraldes P, Goodwill AG, Han B, Heidbreder M, Kobayashi N, Levy BI, Lillioja S, Lindenmeyer MT, Nishikawa T, Noon JP, Ohga S, Olaf Jöhren, Polikandriotis JA, Prewitt RL, Redondo S, Reinhard Eggers, Romeo G, Son NH, Thangarajah H, Vogt CJ, Walter Raasch, Weidner N, Yue Tl TL, Zolk O   +42 more
core   +1 more source

Peroxisomes: surprisingly versatile organelles

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2002
Peroxisome development is a dynamic process that is not yet completely understood. We use the methylotrophic yeast Hansenula polymorpha as model in our studies on peroxisome homeostasis. Cells of this species may contain different types of peroxisomes that differ in protein composition and capacity to incorporate matrix proteins.
Veenhuis, Marten, Klei, Ida J. van der
openaire   +2 more sources

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source