Results 81 to 90 of about 261,210 (338)

Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells

Microbial Cell
Peroxisomes are organelles that are crucial for cellular metabolism, but they also play important roles in non-metabolic processes such as signalling, stress response or antiviral defense. To uncover the consequences of peroxisome deficiency, we compared
Tjasa Kosir, Hirak Das, Marc Pilegaard Pedersen, Ann-Kathrin Richard, Marco Anteghini, Vitor Martins dos Santos, Silke Oeljeklaus, Ida J van der Klei, Bettina Warscheid   +8 more
doaj   +1 more source

Effects of peroxisomal catalase inhibition on mitochondrial function.

Frontiers in Physiology, 2012
Peroxisomes produce hydrogen peroxide as a metabolic by-product of their many oxidase enzymes, but contain catalase that breaks down hydrogen peroxide in order to maintain the organelle’s oxidative balance.
Paul eWalton
doaj   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

Transcriptome Analyses of Procambarus clarkii (Girard, 1852) Under Individual Exposures to CuSO₄, Pendimethalin, and Glyphosate

Toxics
Pesticide usage in the integrated rice–crayfish system has aroused lots of attention all over the world. Especially in China, fish farmers often use copper sulfate and pendimethalin to remove moss from aquaculture water and glyphosate to remove weeds in ...
Yao Zheng, Jiajia Li, Zhuping Liu, Ning Wang, Gangchun Xu   +4 more
doaj   +1 more source

Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]

, 2016
The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana, Mariani, Stefania, Petrangeli, Elisa, Russo, Matteo A., Salvatori, Luisa, Toietta, Gabriele   +5 more
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions

Biomolecules
3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGCR) is one of the rate-limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis.
Jianqiu Wang, Markus Kunze, Andrea Villoria-González, Isabelle Weinhofer, Johannes Berger   +4 more
doaj   +1 more source

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring [PDF]

, 2009
Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known whether a maternal high fat (HF) diet during ...
Bruce, Kimberley D., Byrne, Christopher D., Cagampang, Felino R., Ceriello, Antonio, Didelot, Xavier, Hanson, Mark A., Lehnert, Hendrik, Vatish, Manu, Zhang, F. (Fang), Zhang, Junlong   +9 more
core   +3 more sources

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Sensitive analysis of serum 3α, 7α, 12α,24-tetrahydroxy-5β-cholestan-26-oic acid diastereomers using gas chromatography–mass spectrometry and its application in peroxisomal d-bifunctional protein deficiency

Journal of Lipid Research, 1998
The final steps in bile acid biosynthesis take place in peroxisomes and involve oxidative cleavage of the side chain of C27-5β-cholestanoic acids leading to the formation of the primary bile acids cholic acid and chenodeoxycholic acid.
P. Vreken, A. van Rooij, S. Denis, E.G. van Grunsven, D.A. Cuebas, R.J.A. Wanders   +5 more
doaj   +1 more source