Results 71 to 80 of about 1,161,477 (260)

Estimation of PEX1-mediated Zellweger spectrum disorder births and population prevalence by population genetics modeling

Genetics in Medicine Open
Purpose: Zellweger Spectrum Disorder (ZSD) is a rare syndromic disorder characterized by impaired peroxisome assembly and function. Many cases are due to pathogenic variants in the PEX1 gene and are inherited in an autosomal recessive manner.
Karen E. Malone, Catherine Argyriou, Evelyn Zavacky, Nancy Braverman   +3 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
core   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Parkinson's Disease: Molecular Mechanisms and Treatment Strategies. [PDF]

Records of Pharmaceutical & Biomedical Sciences
Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the elderly, clinically manifested by bradykinesia, resting tremor, postural instability, and hypermyotonia.
Sara Hamed
doaj   +1 more source

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source

Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families

Annals of Medicine
Background Peroxisome biogenesis disorders (PBD) affect multiple organ systems. It is characterized by neurological dysfunction, hypotonia, ocular anomalies, craniofacial abnormalities, and absence of peroxisomes in fibroblasts.
Abdulfatah M. Alayoubi, Ambreen Ijaz, Abdul Wali, Jamil A. Hashmi, Azizah Alharbi, Sulman Basit   +5 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Zellweger Syndrome with Novel PEX1 Variants and Unusual Periventricular Leukomalacia in a Term Infant: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Zellweger syndrome is a rare disorder due to mutations in PEX genes, resulting in defective peroxisome biogenesis and multi-systemic features. This is a case of a male infant born at term via caesarean section due to breech presentation, who experienced ...
Rachana Mahadeva Prasad, Shalini Sankalapura Rangaswamy, Hamsa Mahadevaiah, Mannan Mangal, Gloria Vinoy   +4 more
doaj   +1 more source

Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics

Biomolecules, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder manifesting with upper and lower neuron loss, leading to impairments in voluntary muscle function and atrophy.
Merina Varghese, Wei Zhao, Kyle J. Trageser, Giulio M. Pasinetti   +3 more
doaj   +1 more source