Results 81 to 90 of about 1,161,477 (260)

De novo peroxisome biogenesis revisited [PDF]

, 2014
We describe an alternative peroxisome formation pathway in yeast pex3 and pex19 cells, which relies on the existence of small peroxisomal remnants that are present in these cells.
Ida J. van der Klei, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid, van der Klei, Ida J.   +4 more
core   +2 more sources

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications. [PDF]

Cell Biochem Funct
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Zhang Y, Teng L, Gong L, Fu Y, Qian M.
europepmc   +2 more sources

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Biochemical and clinical profiles of 52 Tunisian patients affected by Zellweger syndrome

Pediatrics and Neonatology, 2017
Background: Zellweger syndrome (ZS) is a peroxisome biogenesis disorder attributed to a mutation of the PEX genes family. The incidence of this disease in Africa and the Arab world remains unknown.
Fahmi Nasrallah, Wiem Zidi, Moncef Feki, Samia Kacem, Neji Tebib, Naziha Kaabachi   +5 more
doaj   +1 more source

Peroxisome assembly: matrix and membrane protein biogenesis

, 2011
The biogenesis of peroxisomal matrix and membrane proteins is substantially different from the biogenesis of proteins of other subcellular compartments, such as mitochondria and chloroplasts, that are of endosymbiotic origin. Proteins are targeted to the
Suresh Subramani, Gaurav Agrawal, Changle Ma   +2 more
core   +1 more source

Advances in the Protective Effects and Mechanisms of β‐Aminoisobutyric Acid in Maintaining Multi‐Organ Homeostasis

Medicine Bulletin, EarlyView.
ABSTRACT β‐Aminoisobutyric acid (BAIBA) is an exercise‐responsive myokine/metabolite released by skeletal muscle and has attracted increasing interest as a potential exercise mimetic and therapeutic candidate in preclinical research. BAIBA acts locally in skeletal muscle and can also reach distal organs through the circulation, contributing to the ...
Hao‐Zhe Wang, Wen‐Bi He, Fei‐Peng Chen, Jiong‐Xing Huang, Lin Zhu, Xiao‐Guang Liu   +5 more
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Genome-wide analysis of effectors of peroxisome biogenesis. [PDF]

, 2010
Peroxisomes are intracellular organelles that house a number of diverse metabolic processes, notably those required for beta-oxidation of fatty acids.
David J Dilworth, Dilworth David J., Shmulevich Ilya, Ramsey A. Saleem, Rose Long-O'Donnell, Long-O'Donnell Rose, Niemistö Antti, Theo A. Knijnenburg, Saleem Ramsey A., Jamakhandi Arvind P., John Boyle, Theo A Knijnenburg, Yakun Wan, Ilya Shmulevich, Abraham M. Armstrong, Arvind P. Jamakhandi, Ramsey A Saleem, Rachubinski Richard A., Antti Niemistö, Boyle John, Abraham M Armstrong, Wan Yakun, John D. Aitchison, Arvind P Jamakhandi, Richard A Rachubinski, John D Aitchison, Richard A. Rachubinski, Armstrong Abraham M., Knijnenburg Theo A., Aitchison John D., David J. Dilworth   +30 more
core   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source