Results 1 to 10 of about 180,178 (295)

Chondrosarcoma and Peroxisome Proliferator-Activated Receptor [PDF]

PPAR Research, 2008
Induction of differentiation and apoptosis in cancer cells by ligands of PPARγ is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS‐27 cells (cell line established from grade III human chondrosarcoma) express PPARγ.
K. Hashizume, T. Ozaki, Y. Kadota, Z. N. Shen, T. Kunisada, K. Nishida   +5 more
doaj   +3 more sources

Peroxisome proliferator–activated receptor delta and liver diseases [PDF]

Hepatology Communications
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes.
Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl   +2 more
doaj   +2 more sources

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects [PDF]

Neural Regeneration Research
Peroxisome proliferator-activated receptor alpha is a member of the nuclear hormone receptor superfamily and functions as a transcription factor involved in regulating cellular metabolism.
Zijun Wu, Yuying Zhao, Shujing Hao, Mengyao An, Chengcheng Song, Jing Li   +5 more
doaj   +2 more sources

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

Frontiers in Pharmacology, 2023
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over 3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally considered key metabolic regulators controlling energy homeostasis in ...
Jiaao Sun, Liyan Yu, Xueling Qu, Tao Huang   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis

Frontiers in Immunology, 2022
Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang, Chang Wang, Ying Shi, Ying Shi, Xiaomei Wang, Xiaomei Wang, Heming Ma, Heming Ma, Quan Liu, Yanhang Gao, Yanhang Gao, Junqi Niu, Junqi Niu   +12 more
doaj   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]

, 2012
Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie, Forkmann, Thomas, Gläsmer, Heide, Margraf, Jürgen, Teismann, Tobias   +4 more
core   +1 more source

Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]

, 2011
Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Desvergne B, Excoffier L, Glas J, Loos BG, Miller SA, Nyman S   +5 more
core   +1 more source

Peroxisome Proliferator-Activated Receptors [PDF]

Hypertension, 2003
Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors acting as transcription factors on numerous target genes after heterodimerization with the retinoid X receptor. PPAR-α and PPAR-γ may be activated by different agonists, although the endogenous ligands are unknown.
Karen L. MacNaul, David E. Moller
openaire   +2 more sources

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Bühren, Jens, Ciufo, David, DeMagistris, Margaret, Hindman, Holly B., Huxlin, Krystel R., Jeon, Kye-Im, MacRae, Scott, Phipps, Richard P., Sime, Patricia J.   +8 more
core   +9 more sources