Results 1 to 10 of about 249,851 (201)

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

PPAR Research, 2010
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten   +3 more
doaj   +2 more sources

Peroxisome proliferator–activated receptor delta and liver diseases [PDF]

Hepatology Communications
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes.
Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl   +2 more
doaj   +2 more sources

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects [PDF]

Neural Regeneration Research
Peroxisome proliferator-activated receptor alpha is a member of the nuclear hormone receptor superfamily and functions as a transcription factor involved in regulating cellular metabolism.
Zijun Wu, Yuying Zhao, Shujing Hao, Mengyao An, Chengcheng Song, Jing Li   +5 more
doaj   +2 more sources

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

Liver Research, 2018
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation and proliferation of adipose tissues. It has
Yoon Kwang Lee, Jung Eun Park, Mikang Lee, James P. Hardwick   +3 more
doaj   +2 more sources

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

Frontiers in Pharmacology, 2023
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over 3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally considered key metabolic regulators controlling energy homeostasis in ...
Jiaao Sun, Liyan Yu, Xueling Qu, Tao Huang   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis

Frontiers in Immunology, 2022
Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang, Chang Wang, Ying Shi, Ying Shi, Xiaomei Wang, Xiaomei Wang, Heming Ma, Heming Ma, Quan Liu, Yanhang Gao, Yanhang Gao, Junqi Niu, Junqi Niu   +12 more
doaj   +1 more source

Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator‐activated receptor α modulator (SPPARMα), versus placebo in patients with non‐alcoholic fatty liver disease

Alimentary Pharmacology and Therapeutics, 2021
Pemafibrate is a novel, selective peroxisome proliferator‐activated receptor α modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non‐alcoholic steatohepatitis (NASH). In patients with dyslipidaemia, it improved serum alanine
A. Nakajima, Yuichiro Eguchi, M. Yoneda, Kento Imajo, N. Tamaki, H. Suganami, T. Nojima, R. Tanigawa, Masakazu Iizuka, Yuki Iida, R. Loomba   +10 more
semanticscholar   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Bühren, Jens, Ciufo, David, DeMagistris, Margaret, Hindman, Holly B., Huxlin, Krystel R., Jeon, Kye-Im, MacRae, Scott, Phipps, Richard P., Sime, Patricia J.   +8 more
core   +9 more sources

Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]

, 2005
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core   +1 more source