Results 1 to 10 of about 249,851 (201)

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

open access: yesPPAR Research, 2010
The peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
Maryam Rakhshandehroo   +3 more
doaj   +2 more sources

Peroxisome proliferator–activated receptor delta and liver diseases [PDF]

open access: yesHepatology Communications
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in transcriptional regulation and play an important role in many physiological and metabolic processes.
Tomoo Yamazaki   +2 more
doaj   +2 more sources

Role of peroxisome proliferator-activated receptor alpha in neurodegenerative diseases and other neurological disorders: Clinical application prospects [PDF]

open access: yesNeural Regeneration Research
Peroxisome proliferator-activated receptor alpha is a member of the nuclear hormone receptor superfamily and functions as a transcription factor involved in regulating cellular metabolism.
Zijun Wu   +5 more
doaj   +2 more sources

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

open access: yesLiver Research, 2018
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation and proliferation of adipose tissues. It has
Yoon Kwang Lee   +3 more
doaj   +2 more sources

The role of peroxisome proliferator-activated receptors in the tumor microenvironment, tumor cell metabolism, and anticancer therapy

open access: yesFrontiers in Pharmacology, 2023
Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over 3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally considered key metabolic regulators controlling energy homeostasis in ...
Jiaao Sun   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis

open access: yesFrontiers in Immunology, 2022
Fibrates, which are agonists of peroxisome proliferator-activated receptor alpha, have received increasing attention in the treatment of primary biliary cholangitis.
Chang Wang   +12 more
doaj   +1 more source

Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator‐activated receptor α modulator (SPPARMα), versus placebo in patients with non‐alcoholic fatty liver disease

open access: yesAlimentary Pharmacology and Therapeutics, 2021
Pemafibrate is a novel, selective peroxisome proliferator‐activated receptor α modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non‐alcoholic steatohepatitis (NASH). In patients with dyslipidaemia, it improved serum alanine
A. Nakajima   +10 more
semanticscholar   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

open access: yes, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO   +7 more
core   +2 more sources

Topical rosiglitazone is an effective anti-scarring agent in the cornea [PDF]

open access: yes, 2013
Corneal scarring remains a major cause of blindness world-wide, with limited treatment options, all of which have side-effects. Here, we tested the hypothesis that topical application of Rosiglitazone, a Thiazolidinedione and ligand of peroxisome ...
Bühren, Jens   +8 more
core   +9 more sources

Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]

open access: yes, 2005
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core   +1 more source

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