The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia
Cells, 2023 Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as preexisting or new-onset hypertension complicated by proteinuria and/or end-organ dysfunction, preeclampsia significantly correlates with maternal and perinatal ...
Iason Psilopatis +3 more
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Chondrosarcoma and Peroxisome Proliferator-Activated Receptor [PDF]
PPAR Research, 2008 Induction of differentiation and apoptosis in cancer cells by ligands of PPARγ is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS‐27 cells (cell line established from grade III human chondrosarcoma) express PPARγ.
K. Hashizume +5 more
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Haematologica, 2017 Imatinib is actively transported by organic cation transporter-1 (OCT-1) influx transporter, and low OCT-1 activity in diagnostic chronic myeloid leukemia blood mononuclear cells is significantly associated with poor molecular response to imatinib ...
Jueqiong Wang +8 more
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The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]
, 2016 The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica +13 more
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Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]
, 2012 Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie +4 more
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Variants of the human PPARG locus and the susceptibility to chronic periodontitis [PDF]
, 2011 Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism.
Desvergne B +5 more
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PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
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Tumor Biology, 2017 Peroxisome proliferator-activated receptor gamma coactivator-1 alpha plays a crucial role in regulating the biosynthesis of mitochondria, which is closely linked to the energy metabolism in various tumors.
Rui Liu +11 more
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Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice [PDF]
, 2017 Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease.
Carta, Davide +9 more
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Journal of Biological Chemistry, 2009 The recent insight that brown adipocytes and muscle cells share a common origin and in this respect are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in ...
N. Petrovic +5 more
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