Results 111 to 120 of about 250,000 (338)

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function. [PDF]

, 2019
Background: Chronic neuropathic pain (NP) is a complex disease that results from damage or presumed damage to the somatosensory nervous system. Current treatment regimens are often ineffective.
Alshelh, Zeynab, Di Pietro, Flavia, Henderson, Luke A, Kosanovic, Danny, Macey, Paul M, Mills, Emily P, Vickers, E Russell   +6 more
core   +1 more source

Peroxisome proliferator-activated receptors: Key regulators of tumor progression and growth

Translational Oncology
One of the main causes of death on the globe is cancer. Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors, including PPARα, PPARδ and PPARγ, which are important in regulating cancer cell proliferation, survival, apoptosis,
Fereshteh Asgharzadeh, Arghavan Memarzia, Vida Alikhani, Sima Beigoli, Mohammad Hossein Boskabady   +4 more
doaj   +1 more source

Correlation between PPARGC1A gene rs8192678 G>A polymorphism and susceptibility to type-2 diabetes

Open Life Sciences, 2019
To systematically investigate the correlation between the G>A polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A or PGC-1alpha) gene rs8192678 locus and the susceptibility to type-2 diabetes mellitus (T2DM).
Du Fei, Yang Kang-Juan, Piao Lian-Shan
doaj   +1 more source

Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Biological Research, 2018
Background Peroxisome proliferator activated receptor alpha (PPARα), a regulator of enzymes involved in β oxidation, has been reported to influence lymphocyte activation.
Ian N. Hines, Michael Kremer, Sherri M. Moore, Michael D. Wheeler   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Coronary Heart Disease

PPAR Research, 2009
Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor γ (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPARG SNPs (C-681G, C-
Jean Dallongeville, Carlos Iribarren, Jean Ferrières, Liisa Lyon, Alun Evans, Alan S. Go, Dominique Arveiler, Stephen P. Fortmann, Pierre Ducimetière, Mark A. Hlatky, Philippe Amouyel, Audrey Southwick, Thomas Quertermous, Aline Meirhaeghe   +13 more
doaj   +1 more source

Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism

Journal of Lipid Research, 2017
α-Chlorofatty aldehydes are generated from myeloperoxidase-derived HOCl targeting plasmalogens, and are subsequently oxidized to α-chlorofatty acids (α-ClFAs). The catabolic pathway for α-ClFA is initiated by ω-oxidation.
ElisaN.D. Palladino, Wen-yi Wang, Carolyn J. Albert, Cédric Langhi, Ángel Baldán, David A. Ford   +5 more
doaj   +1 more source

The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]

, 2008
Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M, Hazra, Saswati, Mao, Jenny T, Peebles, Katherine A, Sharma, Sherven   +4 more
core  

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

PPAR Research, 2007
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription. An important group of transcription factors that mediates the effect of dietary fatty acids and certain
openaire   +4 more sources

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source