Results 171 to 180 of about 250,000 (338)

Could brain-derived neurotrophic factor, irisin, and peroxisome proliferator-activated receptor-gamma be a pathway in cognitive impairment in schizophrenia? [PDF]

BMC Psychiatry
Ünver H, Oruc EB, Yıldırım E, Ergisi S, Yalçındağ A, Dağdeviren A, Örsel S, Erzin G.   +7 more
europepmc   +1 more source

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

Proceedings of the National Academy of Sciences of the United States of America, 2001
W. Oliver, J. L. Shenk, M. Snaith, Caroline Russell, K. D. Plunket, N. Bodkin, M. Lewis, D. Winegar, Marcos L. Sznaidman, Millard H. Lambert, H. Xu, Daniel D. Sternbach, S. Kliewer, B. Hansen, Timothy M. Willson   +14 more
semanticscholar   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2003
Toshiya Tanaka, Joji Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, Y. Ikeda, Mitsuhiro Watanabe, K. Magoori, Ryoichi X. Ioka, K. Tachibana, Yuichiro Watanabe, Y. Uchiyama, Koichi Sumi, Haruhisa Iguchi, S. Ito, T. Doi, T. Hamakubo, M. Naito, J. Auwerx, M. Yanagisawa, T. Kodama, J. Sakai   +21 more
semanticscholar   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Peroxisome Proliferator-Activated Receptor and Age-Related Macular Degeneration

PPAR Research, 2008
Chi-Chao Chan, Jingsheng Tuo, Alexandra A. Herzlich   +2 more
doaj   +1 more source

Glucosylceramide regulates depression through activating peroxisome proliferator-activated receptor gamma in dorsal striatum. [PDF]

Theranostics
Jiang L, He Y, Liu H, Zhang D, Dai Y, Bu Q, Shi Q, Duan H, Zhao Y, Li S, Han S, Zhou Y, Zhao Y, Qin F, Chen Y, Wang L, Li H, Liu C, Qin M, Kuang W, Zhang N, Zhao Y, Cen X.   +22 more
europepmc   +1 more source

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.

Proceedings of the National Academy of Sciences of the United States of America, 1999
T. Leone, C. Weinheimer, D. Kelly
semanticscholar   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

The Furan Fatty Acids 11M5 and 11D5 Can Act as Activators of Human Peroxisome Proliferator-Activated Receptor Gamma. [PDF]

Mol Nutr Food Res
Pospiech J, Caspi A, Vetter W, Kerem Z, Frank J, Kufer TA.   +5 more
europepmc   +1 more source