Results 241 to 250 of about 42,473 (314)

Unraveling the Metabolic Influence of Olfactory Receptors in Cancer Cells

Sensory Neuroscience, EarlyView.
ORs are aberrantly expressed in various tumor types and regulate cancer cell metabolism through nonclassical signaling pathways, including PI3K/Akt, MAPK, and ERK. These receptors influence tumor proliferation, invasion, and immune evasion. Specific OR–ligand interactions offer promising opportunities for targeted cancer therapy and early diagnosis ...
Chengzhilin Li, Xiaochen Gao, Ziheng Liu, Nianlei Zhang, Xue Cao, Wenwen Qi, Chengcheng Liu   +6 more
wiley   +1 more source

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy. [PDF]

Genes (Basel)
Bougnères P, Le Stunff C.
europepmc   +1 more source

Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion

Small Science, EarlyView.
The authors propose a novel use for the conventional hypoglycemic drug, dipeptidyl peptidase IV (DPP4+) inhibitor sitagliptin. Sitagliptin prevents scar formation during wound healing through fibroblast‐to‐adipocyte conversion at least by preventing DPP4‐mediated truncation of IGF‐1.
Ju‐Lei Zhang, Jun‐Nian Zhou, Chao Tang, Yan Li, Wen‐De Yao, Ling‐Li Guo, Zhao‐Yang Chen, Ya‐Li Jia, Quan Zeng, Biao Zhang, Tao Fan, Jia‐Fei Xi, Xue‐Tao Pei, Yan Han, Wen Yue   +14 more
wiley   +1 more source

Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways. [PDF]

Antioxidants (Basel)
Wei X, Manandhar L, Kim H, Chhetri A, Hwang J, Jang G, Park C, Park R.   +7 more
europepmc   +1 more source

Dual‐Targeted Glucose‐Dependent Insulinotropic Polypeptide‐Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue

Small Science, EarlyView.
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie, Lutang Zhao, Shurui Pei, Kaikai Wen, Sijia Fei, Wan Chen, Zhengyang Li, Long Zhang, Linlin Li, Lixin Guo, Hui Huang, Qi Pan   +11 more
wiley   +1 more source

Integrated Use of Oxidative Stress and Histological Biomarkers of T. tinca as Indicators of 17‐Alpha‐Ethynylestradiol Exposure

Environmental Toxicology, EarlyView.
ABSTRACT The potential adverse effects of 17‐alpha‐ethynylestradiol (50, 100, and 500 μg EE2/kg b.w., for 30 days) on tench (Tinca tinca) were evaluated by integrating biomarkers including physiological (hepato‐somatic index, spleen‐somatic index, and hematocrit), oxidative stress (catalase, glutathione peroxidase, and glutathione reductase activities;
Ana L. Oropesa, Alfonso Ramos, Cesar Fallola, Luis J. Gomez   +3 more
wiley   +1 more source

NAD(H) and NADP(H) in plants and mammals.

Mol Plant
Lu D, Grant M, Lim BL.
europepmc   +1 more source

The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization. [PDF]

Plant Direct
Hamade S, Traver MS, Bartel B.
europepmc   +1 more source

Trends in Primary Biliary Cholangitis: Prospective Cohort Study From the European Reference Network Registry (R‐LIVER)

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The European Reference Network on Hepatological Diseases (ERN RARE‐LIVER) is a Europe‐wide network for centers of excellence in the management of rare liver diseases. We aimed to evaluate the current diagnostic and therapeutic trends of primary biliary cholangitis (PBC).
A. Gerussi, E. Nofit, D. P. Bernasconi, C. Kroll, F. Groß, I. Schregel, A. Marini, L. Cristoferi, F. Malinverno, M. Papp, G. Dalekos, E. Rigopoulou, M. K. Janik, P. Milkiewitz, H. Ytting, A. Leburgue, F. Braun, C. Casar, M. Sebode, A. Lohse, B. Hansen, M. Carbone, C. Schramm, P. Invernizzi   +23 more
wiley   +1 more source

Phospholipids and peroxisomes in ferroptosis: the therapeutic target of acupuncture regulating vascular cognitive impairment and dementia. [PDF]

Front Aging Neurosci
Zhang W, Li R, Lu D, Wang X, Wang Q, Feng X, Qi S, Zhang X.   +7 more
europepmc   +1 more source