Results 261 to 270 of about 125,831 (393)

VPS13A Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of VPS13A Disease Patients

Movement Disorders, EarlyView.
Abstract Background Membrane contact sites are crucial for the exchange of ions or lipids and thus are critical for the function and maintenance of organelles. VPS13A is a membrane‐residing, bridge‐like protein connecting two membranes to enable bulk lipid transfer. Loss‐of‐function mutations in the VPS13A gene cause VPS13A disease.
Dajana Grossmann, Adrian Spranger, Emily Fischer, Johanna W. Schubarth, Jenny Leopold, Hannes Glaß, Sebastian Klicker, My Uyen Dang Thi, Anna Elisabeth Bartalis, Andreas Hermann, Kevin Peikert   +10 more
wiley   +1 more source

Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes in <i>Aspergillus nidulans</i>. [PDF]

Mol Biol Cell
Driscoll BE, Fountain MB, Gates IN, Abdollahi R, Langley AM, Owens MB, Christensen JR, Salogiannis J.   +7 more
europepmc   +1 more source

Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networks.

Annals of Botany, 2015
L. Sandalio, M. Romero‐Puertas
semanticscholar   +1 more source

In silico identification of potential drug compound against Peroxisome proliferator-activated receptor-gamma by virtual screening and toxicity studies for the treatment of Diabetic Nephropathy

, 2017
Smrita Singh, Aparajita Mohanty
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Citrate trafficking supports rewiring of mitochondrial metabolism via RTG signaling in yeast osmoadaptation. [PDF]

Biochem J
Primavera A, Laera L, Castegna A, Scarcia P, Palmieri L, Di Noia MA, Guaragnella N.   +6 more
europepmc   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Move over endosymbionts, peroxisomes pass electrons too. [PDF]

Biochem Soc Trans
Walker BJ, Smith EN, Sweetlove LJ.
europepmc   +1 more source

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

Obesity, EarlyView.
ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang, Madison L. Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F. Passos, Diana Jurk, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
wiley   +1 more source

Peroxisome Dysfunction and Steatotic Liver Disease. [PDF]

Int J Mol Sci
Vinoy N, Huang G, Wallace DF, Subramaniam VN.   +3 more
europepmc   +1 more source