Results 271 to 280 of about 42,473 (314)
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Peroxisomes in cardiomyocytes and the peroxisome / peroxisome proliferator-activated receptor-loop
Thrombosis and Haemostasis, 2015SummaryIt is well established that the heart is strongly dependent on fatty acid metabolism. In cardiomyocytes there are two distinct sites for the β-oxidisation of fatty acids: the mitochondrion and the peroxisome. Although the metabolism of these two organelles is believed to be tightly coupled, the nature of this relationship has not been fully ...
Claudia Colasante +3 more
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Hospital Practice, 1985
It is now recognized that absence of normal peroxisomal function is associated with far-reaching and devastating consequences. A group of diverse genetic disorders in which either defective formation of the peroxisome or deficiency of one or more of its constituent enzymes is the central pathogenetic feature has recently been described. Three principal
Hugo W. Moser, Sidney Goldfischer
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It is now recognized that absence of normal peroxisomal function is associated with far-reaching and devastating consequences. A group of diverse genetic disorders in which either defective formation of the peroxisome or deficiency of one or more of its constituent enzymes is the central pathogenetic feature has recently been described. Three principal
Hugo W. Moser, Sidney Goldfischer
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Peroxisomes, lipid metabolism, and peroxisomal disorders
Molecular Genetics and Metabolism, 2004Peroxisomes catalyse a large variety of different cellular functions of which most have to do with lipid metabolism. This paper deals with the role of peroxisomes in three key pathways of lipid metabolism, including: (1) etherphospholipid biosynthesis, (2) fatty acid beta-oxidation, and (3) fatty acid alpha-oxidation.
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2010
Publisher Summary Peroxisomes are single membrane enclosed organelles containing at least one oxidase that forms the toxic molecule H2O2, as well as catalase, an enzyme that breaks the H2O2 down into nontoxic oxygen and water. Since they contain catalase, they are easily identified in electron microscopical sections stained with diaminobenzidine ...
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Publisher Summary Peroxisomes are single membrane enclosed organelles containing at least one oxidase that forms the toxic molecule H2O2, as well as catalase, an enzyme that breaks the H2O2 down into nontoxic oxygen and water. Since they contain catalase, they are easily identified in electron microscopical sections stained with diaminobenzidine ...
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Gluconeogenesis and the peroxisome
Molecular and Cellular Biochemistry, 1997In this article, the capabilities of peroxisomal involvement in the gluconeogenetic processes of vertebrate animals are reviewed in the light of recent findings on peroxisomal metabolism and proliferation. It is demonstrated that the participation of this organelle affords the potential of alternative pathways for the conversion of triacylglycerols to ...
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Peroxisomes and Photomorphogenesis
2013In higher plants, light-grown seedlings exhibit photomorphogenesis, a developmental program controlled by a complex web of interactions between photoreceptors, central repressors, and downstream effectors that leads to changes in gene expression and physiological changes. Light induces peroxisomal proliferation through a phytochrome A-mediated pathway,
Jianping Hu, Jiying Li, Navneet Kaur
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The Cytoplasm: Peroxisomes and Peroxisomal Diseases
2015Peroxisomes are ubiquitous organelles that contain catalase and oxidative enzymes producing H2O2. Depending on cell type, their number, shape, and size vary. By electron microscopy, peroxisomes have a single membrane that encloses a dense matrix that contains a crystalloid core in some species (e.g., rat hepatocytes) but not in others (e.g., human ...
Jürgen Roth, Margit Pavelka
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Seminars in Neonatology, 2002
Peroxisomes are subcellular organelles catalyzing a number of indispensable functions in cellular metabolism. The importance of peroxisomes is stressed by the existence of an expanding number of genetic diseases in which there is an impairment of one or more peroxisomal functions.
Baumgartner, Matthias R +1 more
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Peroxisomes are subcellular organelles catalyzing a number of indispensable functions in cellular metabolism. The importance of peroxisomes is stressed by the existence of an expanding number of genetic diseases in which there is an impairment of one or more peroxisomal functions.
Baumgartner, Matthias R +1 more
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Pharmacological induction of peroxisomes in peroxisome biogenesis disorders
Annals of Neurology, 2000Inherited aberrant peroxisome assembly results in a group of neurological diseases termed peroxisome biogenesis disorders (PBDs). PBDs include three major clinical phenotypes that represent a continuum of clinical features from the most severe form, Zellweger syndrome (ZS), through neonatal adrenoleukodystrophy (NALD) to the least severe form ...
Kirby D. Smith +9 more
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Peroxisomes: Membrane events accompanying peroxisome proliferation
The International Journal of Biochemistry & Cell Biology, 2011Peroxisomes are ubiquitous organelles surrounded by a single membrane that display a variety of metabolic functions. These vary with the organism in which they occur and with environmental conditions. Peroxisomes multiply by division of existing organelles and can be formed from ER.
Łukasz Opaliński +2 more
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