Results 91 to 100 of about 76,980 (312)
Frontiers in Chemistry, 2019 Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics.
Maria L. Odyniec +6 more
doaj +1 more source
Peroxynitrite, a Stealthy Biological Oxidant [PDF]
Journal of Biological Chemistry, 2013 Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide radicals. Peroxynitrite, a reactive short-lived peroxide with a pKa of 6.8, is a good oxidant and nucleophile. It also yields secondary free radical intermediates such as nitrogen dioxide and carbonate radicals.
openaire +2 more sources
Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. [PDF]
, 2005 Peroxynitrite is a potent oxidant and nitrating species proposed as a direct effector of myocardial damage in numerous cardiac pathologies. Whether peroxynitrite also acts indirectly, by modulating cell signal transduction in the myocardium, has not been
Feihl, F. +7 more
core +2 more sources
Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]
, 2020 Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro +6 more
core +1 more source
Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration
Exploration, EarlyView.This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao +11 more
wiley +1 more source
β-Amyloid Accumulation in Neurovascular Units Following Brain Embolism
Journal of Pharmacological Sciences, 2009 Nitric oxide (NO) toxicity is in part mediated by generation of peroxynitrite with concomitant production of superoxide under pathological brain conditions such as ischemia and Alzheimer’s disease.
Feng Han, Kohji Fukunaga
doaj +1 more source
Cytochrome c Nitration by Peroxynitrite [PDF]
Journal of Biological Chemistry, 2000 Peroxynitrite (ONOO(-)), the product of superoxide (O(2)) and nitric oxide (.NO) reaction, inhibits mitochondrial respiration and can stimulate apoptosis. Cytochrome c, a mediator of these two aspects of mitochondrial function, thus represents an important potential target of ONOO(-) during conditions involving accelerated rates of oxygen radical and ...
A M, Cassina +7 more
openaire +2 more sources
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo [PDF]
, 2006 Recent evidence indicates that peroxynitrite represents a major cytotoxic effector in heart diseases, but its mechanisms of action are still not known exactly.
Feihl, F. +6 more
core +1 more source
Protein Energy Malnutrition: Opportunities for Cold Plasma Technologies
Food Frontiers, EarlyView.Protein energy malnutrition (PEM) is a major global health concern driven by biological, environmental, and nutritional factors, including gut microbiota imbalance and low protein intake. Cold atmospheric plasma technologies offer promising, sustainable solutions by improving food security, enhancing protein quality and absorption, and modulating gut ...
Karthika Prasad +6 more
wiley +1 more source
The Interaction of Hypotaurine and Other Sulfinates with Reactive Oxygen and Nitrogen Species:A Survey of Reaction Mechanisms [PDF]
, 2017 Considerable strides have been made in understanding the oxidative mechanisms involved in the final steps of the cysteine pathway leading to taurine.
A Baseggio Conrado +38 more
core +2 more sources