Results 101 to 110 of about 46,884 (257)

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity

BMC Neuroscience, 2018
Background Spinal cord injury (SCI) is one of the leading causes of disability and chronic pain. In SCI-induced pathology, homeostasis of the nitric oxide (NO) metabolome is lost. Major NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite
Mushfiquddin Khan, Tajinder S. Dhammu, Inderjit Singh, Avtar K. Singh   +3 more
doaj   +1 more source

Reactions of peroxynitrite in the mitochondrial matrix

Free Radical Biology and Medicine, 2000
Superoxide radical (O2-) and nitric oxide (NO) produced at the mitochondrial inner membrane react to form peroxynitrite (ONOO-) in the mitochondrial matrix. Intramitochondrial ONOO- effectively reacts with a few biomolecules according to reaction constants and intramitochondrial concentrations.
Valdez, Laura Batriz, Alvarez, Silvia, Lores Arnaiz, Silvia, Schöpfer, Francisco, Carreras, Maria Cecilia, Poderoso, Juan José, Boveris, Alberto Antonio   +6 more
openaire   +3 more sources

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Diffusion of peroxynitrite, its precursors, and derived reactive species, and the effect of cell membranes

Redox Biochemistry and Chemistry
Peroxynitrite is a powerful oxidant formed in vivo in sites where superoxide and nitric oxide coincide. Peroxynitrite is cytotoxic through oxidative modification of target biomolecules that can occur by direct or indirect reactions.
Matías N. Möller, Ana Denicola
doaj   +1 more source

Spectrophotometric studies of the reaction of quercetin with peroxynitrite at different pH

, 2011
Peroxynitrite (ONOOH/ONOO-) which is formed in vivo under oxidative stress is a strong oxidizing and nitrating agent. It has been reported that several flavonoids, including quercetin, inhibit the peroxynitrite-induced oxidation and/or nitration of ...
Katarzyna Stawowska, Lidia Gebicka
core   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

Biomolecules
Although the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source.
Gabriel Simonetti da Silva, Maria Beatriz Braghetto Hernandes, José Carlos Toledo Junior   +2 more
doaj   +1 more source

Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq

Journal of Infection in Developing Countries, 2011
Introduction: Influenza A virus infection is associated with oxidative and nitrosative stress. This study aimed to assess nitrosative stress in pandemic H1N1 (pdmH1N1) and seasonal influenza A infected patients.
Marwan S. M. Al-Nimer, Majid M Mahmood, Saba Saadoon Khazaal   +2 more
doaj   +1 more source

Mechanism of peroxynitrite interaction with cytochrome c. [PDF]

, 2003
Kinetics of the reaction of peroxynitrite with ferric cytochrome c in the absence and presence of bicarbonate was studied. It was found that the heme iron in ferric cytochrome c does not react directly with peroxynitrite.
Gębicka, Lidia, Didik, Joanna
core