Results 101 to 110 of about 84,481 (342)
Top-Down Mass Analysis of Protein Tyrosine Nitration: Comparison of Electron Capture Dissociation with “Slow-Heating” Tandem Mass Spectrometry Methods [PDF]
, 2010 Tyrosine nitration in proteins is an important post-translational modification (PTM) linked to various pathological conditions. When multiple potential sites of nitration exist, tandem mass spectrometry (MS/MS) methods provide unique tools to locate the ...
Cooper, Helen J. +2 more
core +2 more sources
Chemical Communications, 2017 Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high ...
A. Sedgwick +5 more
semanticscholar +1 more source
ChemBioChem, EarlyView.This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang +4 more
wiley +1 more source
Living in an Oxygen Atmosphere – NO• Problem?
CHIMIA, 2001 Formation of nitrogen monoxide in vivo as a signal molecule and as part of the immunological response leads to the formation of oxidized haemoproteins and a powerful oxidant, peroxynitrite.
Susanna Herold, Willem H. Koppenol
doaj
Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease
Frontiers in Physiology, 2020 The mitochondria are a major source of reactive oxygen species (ROS). Superoxide anion (O2•–) is produced by the process of oxidative phosphorylation associated with glucose, amino acid, and fatty acid metabolism, resulting in the production of adenosine
Munehiro Kitada +6 more
doaj +1 more source
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
core +3 more sources
Chemical Science, 2016 A novel fluorescent reporter HKYellow was rationally designed for the robust visualization of peroxynitrite production in live cells and tissues.
T. Peng +6 more
semanticscholar +1 more source
CleanMat, EarlyView.Hydrochar–metal composites with adjustable structures exhibit improved thermal properties for applications like catalysis and energy storage. This review discusses their preparation, phase behavior, and thermal performance, emphasizing metal integration and hydrothermal methods. Challenges involve large‐scale production and phase modeling, while future
Guoqing Liu, Tao Zhang
wiley +1 more source
Boronate based fluorescence (ESIPT) probe for peroxynitrite.
Chemical Communications, 2016 A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement).
A. Sedgwick +5 more
semanticscholar +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source