Results 101 to 110 of about 70,974 (235)
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo [PDF]
, 2006 Recent evidence indicates that peroxynitrite represents a major cytotoxic effector in heart diseases, but its mechanisms of action are still not known exactly.
Feihl, F. +6 more
core +1 more source
Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging
VIEW, EarlyView.Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao +8 more
wiley +1 more source
Peroxynitrite and inflammatory bowel disease [PDF]
Gut, 2000 Idiopathic inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are chronic inflammatory disorders of the gastrointestinal tract which lead an unpredictable clinical course undergoing a succession of exacerbations and remissions of variable intensity.
openaire +2 more sources
VIEW, EarlyView.A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng +7 more
wiley +1 more source
Living in an Oxygen Atmosphere – NO• Problem?
CHIMIA, 2001 Formation of nitrogen monoxide in vivo as a signal molecule and as part of the immunological response leads to the formation of oxidized haemoproteins and a powerful oxidant, peroxynitrite.
Susanna Herold, Willem H. Koppenol
doaj
Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity
BMC Neuroscience, 2018 Background Spinal cord injury (SCI) is one of the leading causes of disability and chronic pain. In SCI-induced pathology, homeostasis of the nitric oxide (NO) metabolome is lost. Major NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite
Mushfiquddin Khan +3 more
doaj +1 more source
The Interaction of Hypotaurine and Other Sulfinates with Reactive Oxygen and Nitrogen Species:A Survey of Reaction Mechanisms [PDF]
, 2017 Considerable strides have been made in understanding the oxidative mechanisms involved in the final steps of the cysteine pathway leading to taurine.
A Baseggio Conrado +38 more
core +2 more sources
Hormonal Treatment During Ex Vivo Lung Perfusion Ameliorates Brain Death Induced Inflammation
Artificial Organs, EarlyView.Treatment of lungs during ex vivo perfusion with 17β‐estradiol and methylprednisolone improved graft quality. In females, treated and non‐treated groups presented reduced leukocyte infiltration and only the treatment improved perfusion flow. In males, treatment improved lung function by increasing compliance, paO2, and perfusion flow.
Marina Vidal‐dos‐Santos +9 more
wiley +1 more source
Nitrostative stress status during seasonal and pdmH1N1 infection in Iraq
Journal of Infection in Developing Countries, 2011 Introduction: Influenza A virus infection is associated with oxidative and nitrosative stress. This study aimed to assess nitrosative stress in pandemic H1N1 (pdmH1N1) and seasonal influenza A infected patients.
Marwan S. M. Al-Nimer +2 more
doaj +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source