Results 201 to 210 of about 76,980 (312)

Paradoxical mitochondrial effects of nitric oxide synthase inhibition following oxygen–glucose deprivation–reoxygenation (OGD/R) in endothelial cells and neurons

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 2, Page 349-363, January 2026.
Background and Purpose Current dogma in stroke is that neuronal nitric oxide synthase (NOS1) exacerbates ischaemic brain injury, while endothelial nitric oxide synthase (NOS3) is protective. However, oxidative stress from ischaemia–reperfusion and oxygen–glucose deprivation‐reoxygenation (OGD/R) is known to uncouple NOS, leading to increased production
Venkata N. Sure   +5 more
wiley   +1 more source

5-Hydroxymethylfurfural: A Particularly Harmful Molecule Inducing Toxic Lipids and Proteins? [PDF]

open access: yesMolecules
Greilberger J   +4 more
europepmc   +1 more source

Comparison of the Effects of Tert-Butyl Hydroperoxide and Peroxynitrite on the Oxidative Damage to Isolated Beef Heart Mitochondria

open access: gold, 2016
Matej Kohutiar   +6 more
openalex   +1 more source

Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPP+‐Induced Parkinson's Disease Model via PPARγ Activation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti‐inflammatory potential of Aesculus hippocastanum (horse chestnut extract, HCE) in an in vitro model of PD.
Sarah Adriana Scuderi   +6 more
wiley   +1 more source

Antenatal melatonin for cardiovascular deficits in fetal growth restriction

open access: yesThe Journal of Physiology, Volume 604, Issue 1, Page 193-213, 1 January 2026.
Abstract figure legend This study used an ovine model of fetal growth restriction (FGR) to investigate the potential cardioprotective effects of melatonin (MLT) in postnatal growth‐restricted lambs. We demonstrated that, while peripheral endothelial function progressively declines between birth and 4 weeks in FGR lambs, FGR+MLT lambs exhibit impaired ...
Charmaine R. Rock   +9 more
wiley   +1 more source

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