Results 181 to 190 of about 37,194 (217)
Some of the next articles are maybe not open access.
Peroxynitrite Scavenging Activity of Indole Derivatives: Interaction of Indoles with Peroxynitrite
Journal of Medicinal Food, 2004One of the products of nitrogen-derived free radicals, peroxynitrite (ONOO(-)), is formed by the reaction of superoxide anion (O(2)(*-)) with nitric oxide (NO). ONOO(-) can cause damage to proteins and DNA through nitration. In particular, proteins and their constituent amino acids have been proven to be extremely sensitive to ONOO(-).
Do Yu, Soung +10 more
openaire +2 more sources
Catalytic scavenging of peroxynitrite by catalase
Journal of Inorganic Biochemistry, 2009Peroxynitrite (ONOO(-)/ONOOH), the product of the diffusion controlled reaction between nitric oxide (*NO) and superoxide anion (O(2)(-)*), is a strong oxidizing and nitrating agent. Several heme proteins react rapidly with peroxynitrite, some of them catalyze its decomposition.
Lidia, Gebicka, Joanna, Didik
openaire +2 more sources
Peroxynitrite-Dependent Tryptophan Nitration
Chemical Research in Toxicology, 1996Peroxynitrite (ONOO-), the reaction product of superoxide (O2.-) and nitric oxide (.NO), nitrates tyrosine and other phenolics. We report herein that tryptophan is also nitrated by peroxynitrite in the absence of transition metals to one predominant isomer of nitrotryptophan, as determined from spectral characteristics and liquid chromatography-mass ...
B, Alvarez +5 more
openaire +2 more sources
The cardiovascular effects and implications of peroxynitrite
Cardiovascular Research, 1999Nitric oxide is an endogenous autacoid produced primarily by the vascular endothelium. Under basal conditions, nitric oxide undergoes a rapid biradical reaction with superoxide anions to form peroxynitrite. This reaction, and hence the formation of peroxynitrite is augmented in inflammatory-like conditions such as ischemia-reperfusion injury when both ...
R S, Ronson +2 more
openaire +2 more sources
Permeation of Phospholipid Membranes by Peroxynitrite
Biochemistry, 2000Quantitative kinetic models have been developed for the reaction between peroxynitrite and membrane lipids in vesicles and for transmembrane oxidation of reactants located within their inner aqueous cores. The models were used to analyze TBARS formation and oxidation of entrapped Fe(CN)(6)(4)(-) ion in egg lecithin liposomes and several artificial ...
R F, Khairutdinov +2 more
openaire +2 more sources
Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo
1995Publisher Summary This chapter examines a number of reaction pathways for nitric oxide, with the emphasis on assessing their biological relevance. Till date, the fastest reaction for nitric oxide with clear toxicological significance is that with superoxide to produce ONOO − . Thus, the chemistry and reactivity of ONOO − are discussed at length.
J P, Crow, J S, Beckman
openaire +2 more sources
Peroxynitrite scavenging by metalloporphyrins and thiolates
Free Radical Biology and Medicine, 2000The rate constant for the reaction of nitric oxide with superoxide virtually assures that peroxynitrite will be formed to some extent in any cell or tissue where both radicals exist simultaneously. The precise biological targets for peroxynitrite and the nature of the modification of those targets vary dramatically depending on their relative ...
openaire +2 more sources
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
Physiological Reviews, 2022Rafael Radi +2 more
exaly