Results 171 to 180 of about 37,194 (217)
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Peroxynitrite and fibrinolytic system: The effect of peroxynitrite on plasmin activity
Molecular and Cellular Biochemistry, 2004We have shown that peroxynitrite (ONOO-) inhibits streptokinase-induced conversion of plasminogen to plasmin in a concentration-dependent manner and reduces both amidolytic (IC5o approximately 280 microM at 10 microM concentration of enzyme) and proteolytic activity of plasmin.
Pawel, Nowak +2 more
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Peroxynitrite, a Stealthy Biological Oxidant [PDF]
Journal of Biological Chemistry, 2013 Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide radicals. Peroxynitrite, a reactive short-lived peroxide with a pKa of 6.8, is a good oxidant and nucleophile. It also yields secondary free radical intermediates such as nitrogen dioxide and carbonate radicals.
Rafael Radi
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Provoking Neuroprotection by Peroxynitrite
Current Pharmaceutical Design, 2004Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological conditions. Initial work addressing the pathophysiology of peroxynitrite afforded the generally accepted notion that this compound would be the long-term neurotoxic nitric oxide-derivative. However, over
Juan P, Bolanos +2 more
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Bactericidal activity of peroxynitrite
Archives of Biochemistry and Biophysics, 1992Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37 degrees C in potassium phosphate, pH 7.4.
L, Zhu, C, Gunn, J S, Beckman
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Peroxynitrite—An ugly biofactor?
BioFactors, 2010AbstractCellular damage occurring under oxidative conditions has been ascribed mainly to the formation of peroxynitrite (ONOOH/ONOO−) that originates from the reaction of NO•with O2•−. The detrimental effects of peroxynitrite are exacerbated by the reaction with CO2that leads to ONOOC(O)O−, which further decays to the strong oxidant radicals NO2•and ...
ASCENZI, Paolo +3 more
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The Reaction of Peroxynitrite with Zeaxanthin
Nitric Oxide, 1998The oxygenated carotenoids zeaxanthin and lutein, found in the macular area of the retina, may offer protection against or repair of oxidative damage associated with the degenerative diseases of aging. Since both superoxide and nitrogen monoxide, which react to form peroxynitrite, are found in the retina, we studied the reaction of peroxynitrite with ...
Scheidegger R +3 more
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Effect of peroxynitrite on erythrocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1996The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities.
M, Soszyński, G, Bartosz
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The Reaction of Ebselen with Peroxynitrite
Chemical Research in Toxicology, 1996Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, rapidly reacts with peroxynitrite, the rate constant being of the order of 10(6) M-1 s-1; the reaction yields the selenoxide of the parent molecule, 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, as the sole selenium-containing product; a stoichiometry of 1 mol of ebselen reacted and of the selenoxide
H, Masumoto, H, Sies
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Effect of peroxynitrite on glutaredoxin
Human & Experimental Toxicology, 2001Glutaredoxin is an important enzyme in thiol homeostasis. As a thioltransferase, it reduces oxidized thiols. It also has dehydroascorbate reductase (DHAR) activity to reduce dehydroascorbate (DHA) to ascorbic acid. Peroxynitrite (ONOO - ) is one of the most active elements of oxidative stress
G, Aykaç-Toker +2 more
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Effects of Lazaroids And A Peroxynitrite Scavenger In A Cell Model Of Peroxynitrite Toxicity
Free Radical Biology and Medicine, 1997We developed a cerebellar granule cell model of peroxynitrite toxicity and showed that certain sulfhydryl-containing compounds (e.g., penicillamine) present as concurrent treatments could inhibit this toxicity. In the present study, 21-aminosteroid and pyrrolopyrimidine lazaroids were tested for cytoprotection in this peroxynitrite toxicity model.
G J, Fici +2 more
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