Results 211 to 220 of about 70,974 (235)
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Propofol Is a Peroxynitrite Scavenger
Anesthesia & Analgesia, 1997P eroxynitrite is a potent oxidant formed by the rapid reaction between nitric oxide and superoxide radical (1). The peroxynitrite anion is relatively stable, but it can rapidly protonate to peroxynitrous acid, an unstable species, which decomposes with a half-life of about one second at pH 7.4 (1,2).
Demiryurek, AT, Kahraman, S
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Peroxynitrite and fibrinolytic system: The effect of peroxynitrite on plasmin activity
Molecular and Cellular Biochemistry, 2004We have shown that peroxynitrite (ONOO-) inhibits streptokinase-induced conversion of plasminogen to plasmin in a concentration-dependent manner and reduces both amidolytic (IC5o approximately 280 microM at 10 microM concentration of enzyme) and proteolytic activity of plasmin.
Pawel, Nowak +2 more
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Peroxynitrite Scavenging Activity of Indole Derivatives: Interaction of Indoles with Peroxynitrite
Journal of Medicinal Food, 2004One of the products of nitrogen-derived free radicals, peroxynitrite (ONOO(-)), is formed by the reaction of superoxide anion (O(2)(*-)) with nitric oxide (NO). ONOO(-) can cause damage to proteins and DNA through nitration. In particular, proteins and their constituent amino acids have been proven to be extremely sensitive to ONOO(-).
Do Yu, Soung +10 more
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Reaction of Retinol with Peroxynitrite
Bioscience, Biotechnology, and Biochemistry, 2007The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-beta-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with ...
Rie, Suzuki +6 more
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Peroxynitrite: From interception to signaling
Archives of Biochemistry and Biophysics, 2016Peroxynitrite is a strong oxidant and nitrating species that mediates certain biological effects of superoxide and nitrogen monoxide. These biological effects include oxidative damage to proteins as well as the formation of 3-nitrotyrosyl moieties in proteins.
Bodo, Speckmann +3 more
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Peroxynitrite-induced cardiac myocyte injury
Free Radical Biology and Medicine, 1996The effects of peroxynitrite (ONOO-) on cultured cardiac myocytes were examined by simultaneous measurements of intracellular Ca2+ ([Ca2+]i) and contractile function. On exposure to 0.2 mM ONOO-, [Ca2+]i increased to beyond the systolic level within 5 min with a concomitant decrease in spontaneous contraction of myocytes followed by complete arrest ...
H, Ishida +4 more
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Peroxynitrite and drug-dependent toxicity
Toxicology, 2005Peroxynitrite is the product of the diffusion-controlled termination reaction between two radicals, nitric oxide and superoxide and is a strong oxidant and nitrating intermediate. Critical biomolecules like proteins, lipids and DNA react with peroxynitrite via direct or radical-mediated mechanisms, resulting in alterations in enzyme activities and ...
Ana, Denicola, Rafael, Radi
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Peroxynitrite Reaction with Heme Proteins
Nitric Oxide, 1999We have reported that low levels of peroxynitrite (PN) can cause inactivation of the heme-thiolate protein prostacyclin (PGI2)-synthase by nitration of a tyrosine residue. To prove that iron catalysis is involved we studied the interaction of PN with microperoxidase and P450nor, a heme-thiolate protein of known structure.
M, Mehl +4 more
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Effect of peroxynitrite on erythrocytes
Biochimica et Biophysica Acta (BBA) - General Subjects, 1996The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities.
M, Soszyński, G, Bartosz
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