Results 61 to 70 of about 70,974 (235)

Role of Peroxynitrite in the Pathogenesis of Parkinson’s Disease and Its Fluorescence Imaging-Based Detection

Biosensors
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting the lives of millions of people worldwide. Although the mechanism underlying PD pathogenesis is largely undefined, increasing evidence indicates that oxidative and ...
Jiye Lv, Feiyu Chen, Changchan Zhang, Yubing Kang, Yan Yang, Chengwu Zhang   +5 more
doaj   +1 more source

Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers
Atheer Awad Mehde, Faridah Yusof, Wesen Adel Mehdi, Raha Ahmed Raus, Layla Othman Farhan, Jwan Abdulmohsin Zainulabdeen, Zaima Azira Zainal Abidin, Hamid Ghazali, Azlina Abd Rahman   +8 more
doaj   +1 more source

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]

, 2013
Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F., Lowes, D. A., Murphy, M. P., Webster, N. R.   +3 more
core   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Linus Hübner, Julia van der Linde   +4 more
wiley   +1 more source

Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome

Journal of Pharmacological Sciences, 2009
We have previously reported that peroxynitrite is involved in dysfunction of nitric oxide (NO)-mediated vasorelaxation in SHR/NDmcr-cp rats (SHR-cp), which display typical symptoms of metabolic syndrome.
Satomi Kagota, Yukari Tada, Namie Nejime, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka   +5 more
doaj   +1 more source

Peroxynitrate formed during a transient episode of brain ischemia increases endothelium-derived hyperpolarization-type dilations in thromboxane/prostaglandin receptor stimulated rat cerebral arteries [PDF]

, 2016
Aim Increased thromboxane A2 and peroxynitrite are hallmarks of cerebral ischemia/reperfusion (I/R). Stimulation of thromboxane/prostaglandin receptors (TP) attenuates endothelium-derived hyperpolarization (EDH).
Balavoine, Boardman, Brzezinska, Bucci, Chamorro, Cipolla, Cipolla, Coucha, Coutts, Crane, Dalle-Donne, Edwards, Ellinsworth, Fluri, Gauthier, George, Ghisdal, Golding, Gorovoy, Hougaard, Hwa, Kilkenny, Koo, Koumura, Kunz, Levina, Li, Liu, Lock, Lu, Luykenaar, Maneen, Maneen, Marrelli, Marrelli, McNeish, McNeish, McNeish, McNeish, Moldovan, Onetti, Palomares, Plane, Prasain, Pérez-Asensio, Rafizadeh, Smeda, Spector, Wakatsuki, Yasmin, Yu   +50 more
core   +2 more sources

100 Years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry [PDF]

Redox Report, 2001
The paper on the unusual properties of a mixture of hydrogen peroxide and nitrous acid by Baeyer and Villiger from 1901 can be regarded as the first report on peroxynitrite. In 1990, Beckman and co-workers suggested that peroxynitrite, formed from the reaction of superoxide with nitrogen monoxide, could be a transient oxidizing species in vivo, a ...
openaire   +2 more sources

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

It's a Gas: Bioconjugation With Vapor‐Phase Reagents

Chemistry – A European Journal, EarlyView.
Gaseous reagents are an emerging class of bioconjugation reagents that can offer alternative selectivity paradigms for the construction of precise bioconjugates. A variety of both inert and highly reactive gases have recently been developed for bioconjugation use.
Yuxuan Ding, Jun Ohata, Zachary T. Ball
wiley   +1 more source