Results 41 to 50 of about 46,884 (257)

Reaction of peroxynitrite with thiols, hydrogen sulfide and persulfides

Redox Biochemistry and Chemistry
Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO−) have established that this stealthy oxidant is formed in biological systems, and that its main targets are carbon dioxide (CO2), metalloproteins and thiols (RSH).
Madia Trujillo, Ernesto Cuevasanta, Lucía Turell, Dayana Benchoam, Gerardo Ferrer-Sueta, Ari Zeida, Celia Quijano, Sebastián Carballal, Rafael Radi, Beatriz Alvarez   +9 more
doaj   +1 more source

Cellular Membrane-Targeted Europium(III) Probe for Selective and Time-Resolved Detection of Peroxynitrite. [PDF]

Chemistry
We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Webb J, Tiffany R, Norvaisa K, Valkenier H, Miebach L, Bekeschus S, Butler SJ.   +6 more
europepmc   +2 more sources

Degradation of Hyaluronan by Peroxynitrite

Archives of Biochemistry and Biophysics, 1997
Treatment of high-molecular-weight hyaluronan (HA) with peroxynitrite at neutral pH (ONOO-/ONOOH) results in altered mobility on agarose gel electrophoresis, as well as reduced limiting viscosity number. Both effects are consistent with a reduction in HA molecular weight.
M, Li, L, Rosenfeld, R E, Vilar, M K, Cowman   +3 more
openaire   +2 more sources

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes

Redox Biology, 2016
There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine.
Yuliya Mikhed, Kai Bruns, Stefan Schildknecht, Michael Jörg, Mobin Dib, Matthias Oelze, Karl J. Lackner, Thomas Münzel, Volker Ullrich, Andreas Daiber   +9 more
doaj   +1 more source

Leishmanicidal activity of peroxynitrite

Redox Report, 1995
Nitric oxide reacts with superoxide to produce peroxynitrite which has been reported to be highly microbicidal to Trypanosoma cruzi in phosphate buffer but ineffective against Leishmania major in culture medium. This contradiction and the potential importance of peroxynitrite as a cytotoxic effector molecule of both macrophages and neutrophils led us ...
R M, Gatti, O, Augusto, J K, Kwee, S, Giorgio   +3 more
openaire   +2 more sources

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Tyrosine nitration in prostaglandin H2 synthase

Journal of Lipid Research, 2002
In this study, we investigated the effects of various nitrogen oxide (NOx) species on the extent of prostaglandin H2 synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells.
Ruba S. Deeb, Matthew J. Resnick, Dev Mittar, Timothy McCaffrey, David P. Hajjar, Rita K. Upmacis   +5 more
doaj   +1 more source

Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. [PDF]

PLoS ONE, 2009
It is well known that excessive non-esterified fatty acids in diabetes contribute to the pathogenesis of renal complications although the mechanism remains elusive.
Hong-Mei Zhang, Howard Dang, Chih-Ko Yeh, Bin-Xian Zhang   +3 more
doaj   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source