Results 31 to 40 of about 37,194 (217)

Leishmanicidal activity of peroxynitrite

Redox Report, 1995
Nitric oxide reacts with superoxide to produce peroxynitrite which has been reported to be highly microbicidal to Trypanosoma cruzi in phosphate buffer but ineffective against Leishmania major in culture medium. This contradiction and the potential importance of peroxynitrite as a cytotoxic effector molecule of both macrophages and neutrophils led us ...
R M, Gatti, O, Augusto, J K, Kwee, S, Giorgio   +3 more
openaire   +2 more sources

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes

Redox Biology, 2016
There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine.
Yuliya Mikhed, Kai Bruns, Stefan Schildknecht, Michael Jörg, Mobin Dib, Matthias Oelze, Karl J. Lackner, Thomas Münzel, Volker Ullrich, Andreas Daiber   +9 more
doaj   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Reaction of peroxynitrite with thiols, hydrogen sulfide and persulfides

Redox Biochemistry and Chemistry
Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO−) have established that this stealthy oxidant is formed in biological systems, and that its main targets are carbon dioxide (CO2), metalloproteins and thiols (RSH).
Madia Trujillo, Ernesto Cuevasanta, Lucía Turell, Dayana Benchoam, Gerardo Ferrer-Sueta, Ari Zeida, Celia Quijano, Sebastián Carballal, Rafael Radi, Beatriz Alvarez   +9 more
doaj   +1 more source

Tyrosine nitration in prostaglandin H2 synthase

Journal of Lipid Research, 2002
In this study, we investigated the effects of various nitrogen oxide (NOx) species on the extent of prostaglandin H2 synthase-1 (PGHS-1) nitration in purified protein and in vascular smooth muscle cells.
Ruba S. Deeb, Matthew J. Resnick, Dev Mittar, Timothy McCaffrey, David P. Hajjar, Rita K. Upmacis   +5 more
doaj   +1 more source

Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. [PDF]

PLoS ONE, 2009
It is well known that excessive non-esterified fatty acids in diabetes contribute to the pathogenesis of renal complications although the mechanism remains elusive.
Hong-Mei Zhang, Howard Dang, Chih-Ko Yeh, Bin-Xian Zhang   +3 more
doaj   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Role of Peroxynitrite in the Pathogenesis of Parkinson’s Disease and Its Fluorescence Imaging-Based Detection

Biosensors
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting the lives of millions of people worldwide. Although the mechanism underlying PD pathogenesis is largely undefined, increasing evidence indicates that oxidative and ...
Jiye Lv, Feiyu Chen, Changchan Zhang, Yubing Kang, Yan Yang, Chengwu Zhang   +5 more
doaj   +1 more source

Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite [PDF]

Free Radical Biology and Medicine, 2009
In this study, we show that boronates, a class of synthetic organic compounds, react rapidly and stoichiometrically with peroxynitrite (ONOO(-)) to form stable hydroxy derivatives as major products. Using a stopped-flow kinetic technique, we measured the second-order rate constants for the reaction with ONOO(-), hypochlorous acid (HOCl), and hydrogen ...
Adam, Sikora, Jacek, Zielonka, Marcos, Lopez, Joy, Joseph, B, Kalyanaraman   +4 more
openaire   +2 more sources