Results 31 to 40 of about 46,884 (257)
Superoxide and peroxynitrite inatherosclerosis. [PDF]
Proceedings of the National Academy of Sciences, 1994 The role of reactive oxygen species in the vascular pathology associated with atherosclerosis was examined by testing the hypothesis that impaired vascular reactivity results from the reaction of nitric oxide (.NO) with superoxide (O2-), yielding the oxidant peroxynitrite (ONOO-).
C R, White +9 more
openaire +2 more sources
Reaction of Astaxanthin with Peroxynitrite [PDF]
Bioscience, Biotechnology, and Biochemistry, 2008 The in vitro reactivities of astaxanthin toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed in order to determine the complete mechanism of this reaction. A series of carotenoids, 13-apo-astaxanthinone (1), 12'-apo-15'-nitroastaxanthinal (2), 12'-apo-astaxanthinal (3), 10'-apo ...
HAYAKAWA, Tsutomu +4 more
openaire +2 more sources
Pteridines, 1999 The effect of pterin-6-aldehyde (P6A), xanthine oxidase inhibitor and superoxide scavenger, on the production of nitrotyrosine as a footprint of tyrosine nitration by peroxynitrite, was compared with that of uric acid, a peroxynitrite scavenger.
Mori Hiroko +5 more
doaj +1 more source
Potential Benefits of Peroxynitrite [PDF]
The Open Pharmacology Journal, 2008 Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of ...
Bobby D, Nossaman, Philip J, Kadowitz
openaire +2 more sources
Diazaborines Resist H2O2-Mediated Oxidation But React Rapidly with Peroxynitrite in Aqueous Buffer [PDF]
, 2021 Arylboronic acids oxidize with H2O2 and peroxynitrite (ONOO-) to yield their corresponding phenols. However, simple arylboronic acids struggle to discriminate between these two biological reactive oxygen species (ROS).
Dylan, Domaille +3 more
core +2 more sources
Peroxynitrite-mediated oxidation of fibrinogen inhibits clot formation
, 1999 The clotting activity of human fibrinogen was fully inhibited in vitro by peroxynitrite. The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 μM at 25°C.
E. Fioretti +11 more
core +2 more sources
Reaction of Retinol with Peroxynitrite
Bioscience, Biotechnology, and Biochemistry, 2007 The reactivity of retinol with peroxynitrite, which is a strong oxidant and has been reported to induce several biological damages, was investigated. 13-cis-14-nitroretinol (1), 13-trans-14-nitroretinol (2), 13-apo-beta-carotenone (3), retinal (4), 11,14-epoxyretinol (5), and 11,15-epoxyretinol (6) were identified as reaction products of retinol with ...
SUZUKI, Rie +6 more
openaire +2 more sources
Angewandte Chemie, EarlyView.A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho +3 more
wiley +2 more sources
Cyclic Hydroxylamines as Monitors of Peroxynitrite and Superoxide-Revisited
Antioxidants, 2021 There is a considerable need for methods that allow quantitative determination in vitro and in vivo of transient oxidative species such as peroxynitrite (ONOOH/ONOO−) and superoxide (HO2•/O2•−).
Uri Samuni, Amram Samuni, Sara Goldstein
doaj +1 more source
Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Advanced Science, EarlyView.A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li +9 more
wiley +1 more source