Results 11 to 20 of about 37,194 (217)
Modulation of Myocardial Contraction by Peroxynitrite [PDF]
Frontiers in Physiology, 2012 Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr +3 more
doaj +3 more sources
Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology [PDF]
Proceedings of the National Academy of Sciences, 1998 Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic ...
D, Salvemini +4 more
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Protection against peroxynitrite [PDF]
FEBS Letters, 1999 Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation.
Arteel, Gavin E. +2 more
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Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Pros and cons of current approaches for detecting peroxynitrite and their applications
Biomedical Journal, 2014 Peroxynitrite, a representative of reactive nitrogen species, plays important roles in the physiological and pathological processes of many oxidative stress-related diseases.
Xingmiao Chen +3 more
doaj +1 more source
Local oxidative and nitrosative stress increases in the microcirculation during leukocytes-endothelial cell interactions. [PDF]
PLoS ONE, 2012 Leukocyte-endothelial cell interactions and leukocyte activation are important factors for vascular diseases including nephropathy, retinopathy and angiopathy.
Saptarshi Kar, Mahendra Kavdia
doaj +1 more source
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase
Cells, 2020 We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and reactive oxygen species.
Ali Mahdi +5 more
doaj +1 more source
Pakistan Journal of Pharmaceutical Sciences, 2020 Peroxynitrite is known as a strong deleterious species that may readily trigger several geriatric diseases via injuring cellular constituents. Proanthocyanidins, a biological flavonoids constituent of Pinus sylvestris L. bark, has been attributed a large
Qingfeng HE +4 more
doaj +1 more source
BMC Neuroscience, 2002 Background Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants
Perno Carlo +9 more
doaj +1 more source
CARDIOVASCULAR EFFECTS OF PEROXYNITRITE [PDF]
Clinical and Experimental Pharmacology and Physiology, 2007 SUMMARYPeroxynitrite (PN) is formed in biological systems from the reaction of nitric oxide (·NO) with superoxide (·) and both exist as free radicals. By itself, PN is not a free radical, but it can generate nitrogen dioxide (·NO2) and carbonate radical (·) upon reaction with CO2.The reaction of CO2constitutes a major pathway for the disposition of PN ...
Rao M, Uppu +6 more
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