Results 11 to 20 of about 46,884 (257)
Peroxynitrite Scavenging by Flavonoids
Biochemical and Biophysical Research Communications, 1997 The peroxynitrite scavenging activity of a series of structurally related flavonoids was tested. It was found that flavonoids are excellent scavengers of peroxynitrite. Compared to the known peroxynitrite scavenger ebselen, the most active flavonoids proved to be 10 times more effective.
Haenen, G.R.M.M. +3 more
openaire +4 more sources
Peroxynitrite: A Putative Cytotoxin
Pharmacology & Toxicology, 1998 Abstract:In recent years it has become apparent that peroxynitrite. which is one of the toxic metabolites originating from the reaction of nitric oxide and superoxide presents a number of pathologic states in which free radicals are thought to be involved.
Demiryurek, AT, Kanzik, I, Cakici, I
openaire +4 more sources
Modulation of Myocardial Contraction by Peroxynitrite [PDF]
Frontiers in Physiology, 2012 Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr +3 more
doaj +3 more sources
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology [PDF]
Proceedings of the National Academy of Sciences, 1998 Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic ...
D, Salvemini +4 more
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Protection against peroxynitrite [PDF]
FEBS Letters, 1999 Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation.
Arteel, Gavin E. +2 more
openaire +2 more sources
Diffusion and Transport of Peroxynitrite across Cell Membranes
, 2023 Peroxynitrite (ONOO−/ONOOH) is a strong oxidant formed in vivo. It is cytotoxic at high concentrations, participates in different diseases and the aging process, and contributes to immune cell response mechanisms to invading organisms.
Zeida, Ari +3 more
core +1 more source
Antioxidants, 2022 Nitrobindins (Nbs) are all-β-barrel heme proteins and are present in prokaryotes and eukaryotes. Although their function(s) is still obscure, Nbs trap NO and inactivate peroxynitrite.
Giovanna De Simone +4 more
doaj +1 more source
, 2021 Peroxynitrite is an important chemical in the human immune system, which has high biocidal activity and can resist the invasion of pathogens. Currently, in vitro generation of peroxynitrite faces major technological challenges, especially for gas-phase ...
Zhou, Renwu +15 more
core +1 more source
Pros and cons of current approaches for detecting peroxynitrite and their applications
Biomedical Journal, 2014 Peroxynitrite, a representative of reactive nitrogen species, plays important roles in the physiological and pathological processes of many oxidative stress-related diseases.
Xingmiao Chen +3 more
doaj +1 more source