Results 71 to 80 of about 76,980 (312)

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection

mBio
There are no licensed vaccines for human cytomegalovirus (HCMV), and current antiviral drugs that target viral proteins are toxic and prone to resistance.
Pragati S. Amratia, Lauren E. Kerr-Jones, Lucy Chapman, Morgan Marsden, Mathew Clement, Richard J. Stanton, Ian R. Humphreys   +6 more
doaj   +1 more source

Near-Infrared Fluorescence Probe for Visualizing Fluctuations of Peroxynitrite in Living Cells and Inflammatory Mouse Models

Chemosensors, 2023
Inflammation is a vital protective response in living systems and closely related to various diseases. As a member of the reactive oxygen species (ROS) family, peroxynitrite (ONOO−) is involved in the organism’s inflammatory process and considered as an ...
Shuchun Qin, Yiming Ran, Yitian He, Xiaoyan Lu, Jiamin Wang, Weili Zhao, Jian Zhang   +6 more
doaj   +1 more source

Alzheimer's disease and HIV associated dementia related genes: I. location and function. [PDF]

, 2008
Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias.
Chiappelli, Francesco, Kayathri, Rajarathinam, Levine, Andrew, Minagar, Alireza, Rodriguez, Hector E, Shapshak, Paul   +5 more
core   +3 more sources

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Human nitrobindin: the first example of an all‐β‐barrel ferric heme‐protein that catalyzes peroxynitrite detoxification

FEBS Open Bio, 2018
Nitrobindins (Nbs), constituting a heme‐protein family spanning from bacteria to Homo sapiens, display an all‐β‐barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is ...
Giovanna De Simone, Alessandra di Masi, Fabio Polticelli, Paolo Ascenzi   +3 more
doaj   +1 more source

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

Journal of Neuroinflammation, 2011
Background Traumatic brain injury (TBI) induces primary and secondary damage in both the endothelium and the brain parenchyma, collectively termed the neurovascular unit.
Gilg Anne G, Im Yeong-Bin, Shunmugavel Anandakumar, Dhammu Tajinder S, Sakakima Harutoshi, Khan Mushfiquddin, Singh Avtar K, Singh Inderjit   +7 more
doaj   +1 more source

Processes for Preparing Peroxynitrite Electrosensitive Depositions and Methods of Selective Detection for Further Biostimulant Screening

Proceedings, 2023
As biostimulants may have a mechanism related to increasing tolerance to abiotic stress (drought, salinity, heat shock, etc., which will increase the production of Reactive Oxygen Species, ROS, such as peroxynitrite (PON)), this work proposes ...
Ioana Silvia Hosu, Anda Maria Baroi, Roxana Ioana Matei (Brazdis), Toma Fistos   +3 more
doaj   +1 more source

Microvascular alterations in hypertension and vascular aging [PDF]

, 2017
Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and
Battistoni, Allegra, Calvez, Valentin, Cesario, Vincenzo, Filippini, Antonio, Montefusco, G, Savoia, Carmine   +5 more
core   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, EarlyView.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source