Results 71 to 80 of about 70,974 (235)

Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection

mBio
There are no licensed vaccines for human cytomegalovirus (HCMV), and current antiviral drugs that target viral proteins are toxic and prone to resistance.
Pragati S. Amratia, Lauren E. Kerr-Jones, Lucy Chapman, Morgan Marsden, Mathew Clement, Richard J. Stanton, Ian R. Humphreys   +6 more
doaj   +1 more source

Near-Infrared Fluorescence Probe for Visualizing Fluctuations of Peroxynitrite in Living Cells and Inflammatory Mouse Models

Chemosensors, 2023
Inflammation is a vital protective response in living systems and closely related to various diseases. As a member of the reactive oxygen species (ROS) family, peroxynitrite (ONOO−) is involved in the organism’s inflammatory process and considered as an ...
Shuchun Qin, Yiming Ran, Yitian He, Xiaoyan Lu, Jiamin Wang, Weili Zhao, Jian Zhang   +6 more
doaj   +1 more source

Microvascular alterations in hypertension and vascular aging [PDF]

, 2017
Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and
Battistoni, Allegra, Calvez, Valentin, Cesario, Vincenzo, Filippini, Antonio, Montefusco, G, Savoia, Carmine   +5 more
core   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Human nitrobindin: the first example of an all‐β‐barrel ferric heme‐protein that catalyzes peroxynitrite detoxification

FEBS Open Bio, 2018
Nitrobindins (Nbs), constituting a heme‐protein family spanning from bacteria to Homo sapiens, display an all‐β‐barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is ...
Giovanna De Simone, Alessandra di Masi, Fabio Polticelli, Paolo Ascenzi   +3 more
doaj   +1 more source

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

Journal of Neuroinflammation, 2011
Background Traumatic brain injury (TBI) induces primary and secondary damage in both the endothelium and the brain parenchyma, collectively termed the neurovascular unit.
Gilg Anne G, Im Yeong-Bin, Shunmugavel Anandakumar, Dhammu Tajinder S, Sakakima Harutoshi, Khan Mushfiquddin, Singh Avtar K, Singh Inderjit   +7 more
doaj   +1 more source

Processes for Preparing Peroxynitrite Electrosensitive Depositions and Methods of Selective Detection for Further Biostimulant Screening

Proceedings, 2023
As biostimulants may have a mechanism related to increasing tolerance to abiotic stress (drought, salinity, heat shock, etc., which will increase the production of Reactive Oxygen Species, ROS, such as peroxynitrite (PON)), this work proposes ...
Ioana Silvia Hosu, Anda Maria Baroi, Roxana Ioana Matei (Brazdis), Toma Fistos   +3 more
doaj   +1 more source

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]

, 2017
open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...

core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. [PDF]

, 2005
Peroxynitrite is a potent oxidant and nitrating species proposed as a direct effector of myocardial damage in numerous cardiac pathologies. Whether peroxynitrite also acts indirectly, by modulating cell signal transduction in the myocardium, has not been
Feihl, F., Levrand, S., Liaudet, L., Pacher, P., Pesse, B., Rolli, J., Schaller, M.D., Waeber, B.   +7 more
core   +2 more sources