Results 71 to 80 of about 84,481 (342)

Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers
Atheer Awad Mehde, Faridah Yusof, Wesen Adel Mehdi, Raha Ahmed Raus, Layla Othman Farhan, Jwan Abdulmohsin Zainulabdeen, Zaima Azira Zainal Abidin, Hamid Ghazali, Azlina Abd Rahman   +8 more
doaj   +1 more source

Microvascular alterations in hypertension and vascular aging [PDF]

, 2017
Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and
Battistoni, Allegra, Calvez, Valentin, Cesario, Vincenzo, Filippini, Antonio, Montefusco, G, Savoia, Carmine   +5 more
core   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Alzheimer's disease and HIV associated dementia related genes: I. location and function. [PDF]

, 2008
Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias.
Chiappelli, Francesco, Kayathri, Rajarathinam, Levine, Andrew, Minagar, Alireza, Rodriguez, Hector E, Shapshak, Paul   +5 more
core   +3 more sources

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants [PDF]

, 1997
It was found that human erythrocytes underwent hemolysis when incubated with peroxynitrite at 37°C under air. The extent of hemolysis increased with increasing peroxynitrite concentration and decreasing hematocrit. The peroxynitrite-induced hemolysis was
Hiroshi Kondo, Mareyuki Takahashi, Etsuo Niki, Moncada, Beckman, Pryor, Radi, Darley-Usmar, Rubbo, Jessup, Hogg, Hayashi, Yamamoto, Niki, Miki, Sandhu, Miki, Ellman, Yamamoto, Niki, Feelish, Whiteman, Salgo, Sies, Masumoto, Jia   +25 more
core   +2 more sources

A chemiluminescent probe for cellular peroxynitrite using a self-immolative oxidative decarbonylation reaction

Chemical Science, 2018
Peroxynitrite is a damaging agent of oxidative stress that has been difficult to monitor in living cells. Here, an isatin-based chemiluminescent probe for peroxynitrite is reported.
Jian Cao, Weiwei An, Audrey G Reeves, Alexander R. Lippert   +3 more
semanticscholar   +1 more source

Bacteria‐Targeted Single‐Atom Nanozyme With Photothermal‐Augmented Multi‐Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing

Advanced Science, EarlyView.
A single‐atom nanozyme‐based multifunctional nanoplatform synergizes bacterial targeting with a NIR‐II responsive therapeutic cascade for effective diabetic wound management. This nanoplatform enhances biofilm destruction through photothermal‐augmented biocatalysis while simultaneously activating endothelial cells by delivering nitric oxide to promote ...
Junyang Chen, Qing Chen, Xudong Qin, Haixia Yang, Xin Wang, Jianliang Zhou, Ying‐Wei Yang, Jian Tian   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

Journal of Neuroinflammation, 2011
Background Traumatic brain injury (TBI) induces primary and secondary damage in both the endothelium and the brain parenchyma, collectively termed the neurovascular unit.
Gilg Anne G, Im Yeong-Bin, Shunmugavel Anandakumar, Dhammu Tajinder S, Sakakima Harutoshi, Khan Mushfiquddin, Singh Avtar K, Singh Inderjit   +7 more
doaj   +1 more source