Results 31 to 40 of about 4,999,106 (187)

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

Scientific Reports, 2017
Three-dimensional in vitro cell systems are a promising alternative to animals to study cardiac biology and disease. We have generated three-dimensional in vitro models of the human heart (“cardiac spheroids”, CSs) by co-culturing human primary or iPSC ...
Liudmila Polonchuk, Mamta Chabria, Laura Badi, Jean-Christophe Hoflack, Gemma Figtree, Michael J. Davies, Carmine Gentile   +6 more
doaj   +1 more source

Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells

Redox Biology, 2023
Diabetes mellitus currently affects ∼10% of the population worldwide, with Type 2 predominating, and this incidence is increasing steadily. Both Type 1 and 2 are complex diseases, involving β-cell death and chronic inflammation, but the pathways involved
Ramona Clemen, Eduardo Fuentes-Lemus, Sander Bekeschus, Michael J. Davies   +3 more
doaj  

Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.

PLoS ONE, 2017
BACKGROUND:An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic ...
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield   +9 more
doaj   +1 more source

Kinetics of Bacterial Inactivation by Peroxynitric Acid in the Presence of Organic Contaminants

Applied and Environmental Microbiology, 2021
A good disinfectant for the human body should have various properties, such as strong bactericidal activity, harmlessness to living tissues, and resistance against biological fluids (or other organic contaminants). Peroxynitric acid (PNA) showed a bactericidal effect that was several tens up to several hundred times higher per unit of molarity than ...
Takashi Yokoyama, Shinya Miyazaki, Hiroko Akagi, Satoshi Ikawa, Katsuhisa Kitano   +4 more
openaire   +3 more sources

Inferring ozone production in an urban atmosphere using measurements of peroxynitric acid [PDF]

Atmospheric Chemistry and Physics, 2009
Abstract. Observations of peroxynitric acid (HO2NO2) obtained simultaneously with those of NO and NO2 provide a sensitive measure of the ozone photochemical production rate. We illustrate this technique for constraining the ozone production rate with observations obtained from the NCAR C-130 aircraft platform during the Megacity Initiative: Local and ...
Denise D. Montzka, James H. Crawford, Christopher A. Cantrell, D. McCabe, D. McCabe, Andrew J. Weinheimer, K. M. Spencer, John D. Crounse, Jennifer R. Olson, Rebecca S. Hornbrook, D. J. Knapp, Roy L. Mauldin, Paul O. Wennberg   +12 more
openaire   +6 more sources

Degradation of 1,4-dioxane by reactive species generated during breakpoint chlorination: Proposed mechanisms and implications for water treatment and reuse

Journal of Hazardous Materials Letters, 2022
Breakpoint chlorination, an important chemical process relevant to chlorine-based advanced oxidation processes for potable reuse and to traditional water treatment, was investigated for its oxidative capacity, generation of reactive species, and ...
Samuel D. Patton, Michael C. Dodd, Haizhou Liu   +2 more
doaj  

Oxidative/Nitrosative Stress, Apoptosis, and Redox Signaling: Key Players in Neurodegenerative Diseases

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 1, January 2025.
Enzymatic and nonenzymatic antioxidant defense mechanisms are activated to counteract the detrimental effects of augmented free radicals, oxidants, and nitrogen compounds within the cell. ABSTRACT Neurodegenerative diseases are significant health concerns that have a profound impact on the quality and duration of life for millions of individuals. These
Nuray Üremiş, Muhammed Mehdi Üremiş
wiley   +1 more source

Plasma–Liquid Interaction for Agriculture—A Focused Review

Plasma Processes and Polymers, Volume 22, Issue 1, January 2025.
This article presents an overview of the applications of plasma activated water (PAW) in the field of agriculture, focusing on the chemistry of long‐lived reactive species and their roles in plant cell mechanisms. We describe different types of discharges for the production of PAW and its application to seeds and plants.
N. Puač, N. Škoro
wiley   +1 more source

“Production and Chemical Composition of Plasma Activated Water: A Systematic Review and Meta‐Analysis”

Plasma Processes and Polymers, Volume 22, Issue 1, January 2025.
This systematic review provides a comprehensive analysis of the different methodologies for producing plasma activated water, with a particular focus on how process parameters influence the concentration of reactive oxygen and nitrogen species in PAW. The review synthesizes findings from 358 original studies published between 2017 and 2023.
Roberto Montalbetti, Zdenko Machala, Matteo Gherardi, Romolo Laurita   +3 more
wiley   +1 more source

Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

Redox Biology, 2020
The precise characterization and quantification of oxidative protein damage is a significant challenge due to the low abundance, large variety, and heterogeneity of modifications.
Luke F. Gamon, Chaorui Guo, Jianfei He, Per Hägglund, Clare L. Hawkins, Michael J. Davies   +5 more
doaj