Results 81 to 90 of about 52,578 (283)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Jovan Vladimir of Dioclea and Medieval Ruler Martyrs: To Persevere in Love »Until the End«
Edinost in Dialog, 2020 Prince Jovan Vladimir of Dioclea (Duklja, present-day Montenegro), who lived at the beginning of the 11th century, is regarded as the earliest known Slavic saint from the Western Balkans.
Simon Malmenvall
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Perseverance: Psychospiritual and Genetic Perspectives [PDF]
, 2016 Perseverance constitutes a quality that motivates humankind to press onward usually in the face of significant adversity and resistance. Perseverance is also important in the Christian life. The apostle Paul, using athletic training metaphors, frequently
Johnston, Arielle +2 more
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Perseverance, cognitive skills and life outcomes.
We study the early-life determinants of children's perseverance and its predictive power for educational attainment and labour market outcomes across the life course. Using teacher-assessed perseverance from the 1970 British Cohort Study we document that
Fe, Eduardo, Jahangir, Sabaa
core +7 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Towards a Transversal Definition of Psychological Resilience: A Literature Review
Medicina, 2019 Background and objectives: This paper addresses psychological resilience, a multidisciplinary theoretical construct with important practical implications for health sciences.
Antonella Sisto +5 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Perseverance as an Intellectual Virtue
, 2020 philosopher has undertaken an extended treatment of perseverance as an intellectual virtue. In the present paper, I take up this task. An inquiry into the nature of intellectual perseverance is worthwhile for several reasons.
Nathan L King
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