Results 71 to 80 of about 2,614,626 (301)

Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers

Frontiers in Veterinary Science, 2020
Foot-and-mouth disease virus (FMDV) causes persistent infection of nasopharyngeal epithelial cells in ~50% of infected ruminants. The mechanisms involved are not clear. This study provides a continued investigation of differentially expressed genes (DEG)
James J. Zhu, Carolina Stenfeldt, Carolina Stenfeldt, Elizabeth A. Bishop, Jessica A. Canter, Jessica A. Canter, Michael Eschbaumer, Luis L. Rodriguez, Jonathan Arzt   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection. [PDF]

, 2012
The human cytomegalovirus (HCMV) is suspected to increase tumour malignancy by infection of cancer and/or stroma cells (oncomodulation). So far, oncomodulatory mechanisms have been attributed to the presence of HCMV and direct action of its gene products
Hackmann, K.,, Steinberger, D., Griffin, D.K., Breitling, Rainer, Barth, Susanne, Griffin, D.K.,, Breitling, R., Cinatl, J., Doerr, Hans Wilhelm, Rothweiler, Florian, Steinberger, D, Michaelis, M.,, Cinatl, J.,, Hackmann, Karl, Rothweiler, F., Schröck, E, Breitling, R.,, Cinatl Jr., J.,, Schröck, Evelin, Hackmann, K., Michaelis, Martin, Cinatl, Jindrich, Bruch, J., Bruch, J.,, Schröck, E., Doerr, H. W., Hackmann, K, Steinberger, Daniela, Barth, S., Cinatl Jr., J., Griffin, D. K., Doerr, H.W.,, Rothweiler, F.,, Michaelis, M., Bruch, James C., Cinatl, Jaroslav, Doerr, H.W., Bruch, Jochen, Steinberger, D.,, Griffin, Darren K., Schröck, E.,, Barth, S.,   +41 more
core   +13 more sources

Leaderless FMDV is fully attenuated in vivo and unable to establish persistent infection

, 2023
International audienceMany ways of attenuation of foot-and-mouth disease virus (FMDV) have been ex-plored. One successful method is the deletion of most of the coding sequence for the Leader proteinase Lpro.
Pfaff, Florian, Romey, Aurore, Eschbaumer, Michael, Landmesser, Anja, Blaise-Boisseau, Sandra, Sehl-Ewert, Julia, Beer, Martin, Litz, Benedikt   +7 more
core   +3 more sources

The Effect of Amoxicillin Pre-Exposure on Treatment Outcomes and Antimicrobial Susceptibility in Patients with Urogenital Chlamydia trachomatis Infection

Infection and Drug Resistance, 2023
Cong You,1 Mingyi Liao,1 Mei Wang,2 Leran Zhao,3 Longnian Li,1 Xiaoying Ye,1 Tao Yang1 1Department of Dermatology and Venereology; Candidate Branch of National Clinical Research Centre for Skin and Immune Diseases, the First Affiliated Hospital of Gannan
You C, Liao M, Wang M, Zhao L, Li L, Ye X, Yang T   +6 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

DYNAMICS OF PERSISTENT INFECTIONS IN HOMOGENEOUS POPULATIONS

International Journal of Bifurcation and Chaos, 2012
Modeling the dynamics of persistent infections presents several challenges. These diseases are characterized by long latency periods, which makes it compulsory to consider populations of varying sizes. In this paper, we discuss a model for the spreading of persistent infections in homogeneous, well-mixed, populations.
Joaquín Sanz, Luis Mario Floría, Yamir Moreno   +2 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source