Results 91 to 100 of about 5,871,341 (301)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Determinants of diagnostic prototypicality judgments of the personality disorders [PDF]
, 1990 The recent advent of the third edition of the Diagnostic and Statistical Manual of Mental Disorders represented a major shift from a monothetic to a polythetic system for the categorization of psychopathology.
Herbert, Diana Lee +1 more
core
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source
Borderline Personality Disorder
Evolution, Medicine and Public Health, 2016 The term ‘Borderline Personality Disorder’ (BPD) refers to a psychiatric syndrome that is characterized by emotion dysregulation, impulsivity, risk-taking behavior, irritability, feelings of emptiness, self-injury and fear of abandonment, as well as ...
M. Brüne
semanticscholar +1 more source
Zuckerman’s personality model predicts MCMI-III personality disorders [PDF]
, 2007 The current study explores the relationships between the basic dimensions of the Zuckerman personality model (measured through the ZKPQ) and the 14 personality disorder scales of the millon clinical multiaxial inventory third edition (MCMI-III).
García, Luis F. +5 more
core +1 more source
Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton +4 more
wiley +1 more source
Frontiers in PsychiatryIn recent years, stress-monitoring innovations using wearable technology have entered the market. One innovation is biocueing, a process where patients receive real-time feedback on passive monitoring of significant changes in their physiological data ...
Luuk L. Lans +8 more
doaj +1 more source
A Metastructural Model of Mental Disorders and Pathological Personality Traits
Psychological Medicine, 2015 Background Psychiatric co-morbidity is extensive in both psychiatric settings and the general population. Such co-morbidity challenges whether DSM-based mental disorders serve to effectively carve nature at its joints.
A. Wright, Leonard J. Simms
semanticscholar +1 more source
, 2019 Neurodevelopmental disorders, such as Autism Spectrum Disorders (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD), express aberrant neurocognitive functions in social communication, flexibility, and executive control from an early age, not seldom
Anckarsäter, Henrik, +4 more
core +1 more source