Results 71 to 80 of about 5,871,341 (301)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Psychometric properties of the Pride in Eating Pathology Scale in a Spanish population

Journal of Eating Disorders, 2023
Background In its relation to eating disorders, pride is one of the self-conscious emotions least analyzed, and requires valid and reliable instruments for its measurement.
Juan Francisco Rodríguez-Testal, Juana M. Trinidad-Montero, Ángela Rosales Becerra, Cintia Faija, Cristina Senín-Calderón   +4 more
doaj   +1 more source

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

Nature Genetics, 2016
Personality is influenced by genetic and environmental factors and associated with mental health. However, the underlying genetic determinants are largely unknown.
Min-Tzu Lo, D. Hinds, J. Tung, C. Franz, Chun C. Fan, Yun-Peng Wang, O. Smeland, A. Schork, D. Holland, K. Kauppi, Nilotpal Sanyal, V. Escott-Price, Danny J. Smith, M. O'Donovan, H. Stefánsson, G. Bjornsdottir, T. Thorgeirsson, K. Stefánsson, L. McEvoy, A. Dale, O. Andreassen, Chi-Hua Chen   +21 more
semanticscholar   +1 more source

The role of positive and negative childhood events in the risk of developing personality disorders [PDF]

, 2015
Existing research has predominantly focused on a limited range of childhood events and personality disorders, such as childhood maltreatment and borderline personality disorder.
Chua, M
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An exploration of clinicians' experiences in the diagnosis and management of patients with borderline personality disorder [patients] at Valkenberg hospital in the Western Cape region [PDF]

, 2007
Includes bibliographical references (leaves 66-80).Disorders of personality are conceptualized along a continuum of severity. Among all diagnosed with a cluster B personality disorder, patients with Borderline Personality Disorder illness are believed to
Gqiba, Nobuntu
core   +1 more source

Patient and therapist perspectives on impact, outcomes and change mechanisms in trauma-focused mentalization-based treatment: a qualitative interview study

Frontiers in Psychiatry
IntroductionComplex trauma is common in individuals with borderline personality disorder (BPD) and linked to persistent difficulties in emotion regulation, self-concept, and relationships.
Maaike L. Smits, Maaike L. Smits, Ilse M. Krah, Janine K. Driessen, Bram W. Kuppens, Arjen Noordhof   +5 more
doaj   +1 more source

Family logotherapy

Fides et Ratio, 2022
The paper outlines the concept of family logotherapy in relation to systemic family therapy, popular in Poland. The basic philosophical and anthropological assumptions of Frankl’s logotherapy, and thus the phenomenon of free will, as well as the will to
Kasper Sipowicz, Marlena Podlecka , Tadeusz Pietras   +2 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source