Results 131 to 140 of about 2,588,848 (267)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Exploring the potential benefits of growth hormone co-treatment on embryo quality in IVF: a randomized controlled open-label trial

Reproductive Biology and Endocrinology
Research question While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive.
Yi Tang, Xiaofeng Li, Change Hu, Ruyi Guan, Zhimin Wang, Shunji Zhang, Guoping Tao, Jingfei Qu, Fei Gong   +8 more
doaj   +1 more source

Evaluation of the Embryo Transfer Procedure Proposed by the International Embryo Transfer Society (IETS) as a Method of Controlling Vertical Transmission of Neospora caninum in Cattle

, 2001
New infections by Neospora caninum in cattle occur primarily following vertical transmission, and there is no proven way to prevent it. The embryo transfer procedure proposed by the International Embryo Transfer Society (IETS) has been proven effective ...
Fecteau, Gilles, Sauvé, Roger, Baillargeon, Paul, Paré, Julie, Lamothe, Pierre   +4 more
core   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Development and Validation of a Combined Model Integrating Early Pregnancy Ultrasound Radiomics and Clinical Features to Predict Live Birth Following Single Vitrified‐Warmed Blastocyst Transfer

Reproductive Medicine and Biology
Objective To develop and validate a predictive model for live birth following single vitrified‐warmed blastocyst transfer (SVBT) by integrating early pregnancy ultrasound radiomics with clinical parameters.
Lidan Liu, Bo Liu, Dongliu Xu, Huimei Wu, Li Jiang, Lang Qin   +5 more
doaj   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

The Role of GnRH Agonist Therapy and Hysterosalpingography (HSG) in Diagnosing and Treating Tubal Factor Infertility

Journal of Pharmacy and Bioallied Sciences
The paper describes the treatment of a 27-year-old woman with a history of infertility, heavy menstrual periods, and severe endometriosis with bilateral hydrosalpinx.
Dipti Katre, Namrata Choudhary, Ashish Prakash Anjankar, Aakash More, Sudhanshu Dakre   +4 more
doaj   +1 more source

Success of frozen embryo transfer: Does the type of gonadotropin influence the outcome?

, 2010
Hesham Al-Inany1, Pieter van Gelder21Egyptian IVF-ET Center, Maadi, Egypt; 2PSCT BV, Den Haag, The NetherlandsObjectives: To determine whether there is a difference in outcome between different ovulationinduced cycles after frozen-thawed embryo transfer (
Hesham Al-Inany, Pieter van Gelder
core  

Treatment cycles of fresh embryo transfer stratified by seasons.

, 2018
Treatment cycles of fresh embryo transfer stratified by seasons.
Michal Kirshenbaum (5484788), Raoul Orvieto (621454), Eran Zilberberg (5484794), Alon Ben-David (5484791), Jigal Haas (497908), Tal Elkan-Miller (225592)   +5 more
core   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source