Results 101 to 110 of about 2,557,779 (357)
Dignidad y autonomía. Reflexiones sobre la tradición kantiana
Estudios de Filosofía, 2019 La idea kantiana según la cual sólo las personas pueden pretender respeto (“dignidad”) y sólo frente a ellas pueden existir derechos morales, aunque, al mismo tiempo, no todos los seres humanos son personas en este sentido prescriptivo estricto, contiene
Thomas Gutmann, Carlos Rendón Arroyave
doaj +1 more source
, 2021 Dementia shows us human existence without any decoration. We see it is heartbreaking, fragile, and delicate in all details. And we see more similarities than differences in our lives than we might imagine. We are all familiar with sadness, joy, fear, despair, depression, and happiness. People who have dementia feel the same way. Sadly, emotions confuse
openaire +1 more source
Helping a visually impaired student to improve her social interaction skills at Andrés Bello University, Viña del Mar, Chile : an action research [PDF]
, 2018 Tesis (Pedagogía en Inglés)During the last decade, inclusion that is “Something which cannot be done to people, it is something in which people are actively involved” (Norwich, 1999), has been used by different educational institutions to define or ...
Aguirre Reyes, Ivette Lissette +3 more
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
La participación de las personas mayores en talleres y su efecto sobre la soledad [PDF]
, 2019 Treball Final de Grau en Psicologia. Codi: PS1048. Curs: 2018/2019.Es importante valorar que la calidad de vida de una persona no solo está determinada por la salud física, sino también por la emocional. Existen evidencias del efecto que la soledad o el
Esteve Grifo, Marina
core
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Personas jurídicas de Derecho especial [PDF]
, 2006 El artículo presenta una reseña del libro "Personas jurídicas de Derecho especial", escrito por Jaime Baquero de la Calle ...
Vázquez-García-Peñuela, J.M. (Jose María)
core
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source