Results 131 to 140 of about 2,782,172 (355)

Usability evaluation of digital libraries: a tutorial [PDF]

open access: yes, 2003
This one-day tutorial is an introduction to usability evaluation for Digital Libraries. In particular, we will introduce Claims Analysis. This approach focuses on the designers’ motivations and reasons for making particular design decisions and ...
Blandford, A., Fields, B., Keith, S.
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

'Surviving the Wilds of Academia': Personas Depicting Early-Career Engineering Education Scholars Role Crafting to Achieve Their Goals

open access: yesStudies in Engineering Education
Background: The increase in doctoral programs and certifications in the area of engineering education has led to an increase in Engineering Education Scholars (EES) on the job market.
Cheryl A. Bodnar   +5 more
doaj   +1 more source

Using System Analysis and Personas for e-Health Interaction Design [PDF]

open access: yes, 2009
Today, designers obtain more central roles in product and service development (Perks, Cooper, & Jones, 2005). They have to deal with increasingly complicated problems, like integrating the needs of various stakeholders while taking care about social ...
Bredies, Katharina
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Surgical personae [PDF]

open access: yesThe Annals of The Royal College of Surgeons of England, 2018
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Efecto de una intervención no farmacológica multidimensional en un grupo de personas con deterioro cognitivo leve [PDF]

open access: diamond, 2021
Carolina Ruiz-Tagle   +8 more
openalex   +1 more source

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