Results 131 to 140 of about 5,838,612 (374)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Perspective Taking and Advance Directives

AMA Journal of Ethics, 2010
New brain imaging suggests that asking patients to put themselves in their surrogates’ shoes when thinking about advance directives might lead to directives that better line up with what surrogates think they should decide. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +3 more sources

Corporate governance and industrial relations in Poland [PDF]

, 2003
The paper discusses Polish privatisation from the industrial relations point of view. It focuses on the role of trade unions and workers councils in the privatisation process. Two polar privatisation blueprints are identified: those aiming at competitive
Federowicz, M.
core  

Cognitive Mechanisms underlying visual perspective taking in typical and ASC children [PDF]

, 2016
Previous research has suggested that people with Autism Spectrum Conditions (ASC) may have difficulty with visual perspective taking (VPT) but it is not clear how this relates to different strategies that can be used in perspective taking tasks.
Aichhorn, Baron-Cohen, Berument, Bosbach, Dawson, Devries, Dowell, Dunn, Eigsti, Farrant, Flavell, Flavell, Frith, Frith, Frith, Gardner, Geiser, Grush, Ham, Hamilton, Hamilton, Happe, Joseph, Kessler, Kessler, Kessler, Langdon, Liddle, Muth, Pearson, Reed, Schurz, Senju, Surtees, Surtees, Tan, Tessari, Wellman, Wimmer, Yirmiya, Yu, Zacks   +41 more
core   +2 more sources

PISA 2022 insights on intellectual curiosity, perspective-taking, and science achievement: Examining the mediating pathways

International Journal of Educational Research Open
The purpose of the study is to investigate the predictive roles of intellectual curiosity and perspective-taking on science achievement among Emirati early adolescents. Utilizing data from 24,600 participants of the 2022 Program for International Student
Othman Abu Khurma, Adeeb Jarrah, Nagla Ali   +2 more
doaj   +1 more source

Standing in my customer's shoes: Effects of customer‐oriented perspective taking on proactive service performance

Journal of Occupational and Organizational Psychology, 2018
We develop a theoretical framework that delineates the process by which customer-oriented perspective taking contributes to employees’ proactive service performance.
Y. Huo, Ziguang Chen, W. Lam, Stephen A. Woods   +3 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Taking different perspectives on a story. [PDF]

, 1977
James W. Pichert, Richard C. E. Anderson
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source