Results 51 to 60 of about 3,799,588 (281)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Does the Need for Control Hinder Sense of Presence in Virtual Reality?

Psychologica Belgica
Virtual reality (VR) has witnessed significant growth in the mental health field. However, clinical observations reveal substantial variability across individuals’ responses to VR.
Romane Michaux, Céline Stassart, Aurélie Wagener   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Examining the Relationships Between Perceived Social Support and Cognitive Emotion Regulation and Emotional Reactivity

, 2022
The aim of this study is to investigate how emotional reactivity is affected by adaptive and maladaptive cognitive emotion regulation and perceived social support.
Ezgi Dilan YILDIRIM, Tolan, Özlem Çakmak, Özlem ÇAKMAK TOLAN, Serdem Benan TÜMER, Yıldırım, Ezgi Dilan, Tümer, Serdem Benan   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Les villes nordiques, une ingéniosité territoriale par nécessité [PDF]

, 2019
Tandis que de nombreuses villes françaises courent encore après l’éco-quartier qui leur fournira un laboratoire scintillant attestant, espace à l’appui, d’une obsession soudaine pour la durabilité, le lierre a progressivement gagné Hedebygade.
Nilsson, Håkan, Birk Jørgensen, Morten,, Kervanto Nevanlinna, Anja,, Lindstrand, Tor, Kervanto Nevanlinna, Anja, Escach, Nicolas,, Lindstrand, Tor,, Høegh Stigsen, Bilo,, Birk Jørgensen, Morten, Nevanlinna, Anja Kervanto,, Stigsen, Bilo Hoegh,, Nilsson, Håkan,, Høegh Stigsen, Bilo, Escach, Nicolas, Jorgensen, Morten Birk,   +14 more
core   +1 more source

DEVELOPMENT OF SYSTEM OF THE MULTIPURPOSE CENTERS OF PROVIDING THE STATE AND MUNICIPAL SERVICES TO THE POPULATION (ON THE EXAMPLE OF PRIMORSKY KRAI)

RUDN Journal of Public Administration, 2016
The article deals with improving the quality of the provision and accessibility of public and municipal services. With the rapid development of telecommunications technology procedures for obtaining services and information to signifi cantly expand and ...
Eugeniya O Zapoleva, Anna A Zakharchenko, Victor V Pit, Elena S Mudrik   +3 more
doaj  

The broad positive health perspective on health as common ground for tackling current and future interdisciplinary health challenges

Frontiers in Public Health
In the past decades, many developments on economy, demography and technology amongst others have directly or indirectly influenced population health both in a positive and negative way.
John A. J. Dierx, Cindy M. A. De Bot
doaj   +1 more source

Perspectives … [PDF]

Perspectives on Medical Education, 2012
None
openaire   +3 more sources