Results 101 to 110 of about 5,916,385 (282)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Through benevolent eyes: the differential efficacy of perspective taking and cognitive reappraisal on the regulation of shame

, 2020
Difficulties in regulating feelings of shame is a risk factor for the onset and recurrence of mental health disorders. The present research investigated the impact of the individual differences in propensity to experience shame (or shame-proneness) on ...
O'Donovan, Analise, Mullens, Amy, Davis, Penelope, McDermott, Brett, Krishnamoorthy, Govind   +4 more
core   +1 more source

Awe and Perspective taking [PDF]

, 2020
Understanding another’s perspective is an essential component of a healthy social interaction. However, the motivation to empathize with others can often be low. My thesis investigated whether the emotion of awe may motivate perspective taking.
Li, Yachen
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Spatial perspective taking is distinct from cognitive and affective perspective taking.

Journal of Experimental Psychology: General
Abstract Perspective taking (PT) is the ability to imagine viewpoints different from our own. However, the nature of PT as a construct, and its underlying cognitive mechanisms, are not well established. Some researchers propose that understanding what others believe (cognitive PT), feel (affective PT), and see (spatial PT) form a single
Maria Brucato, Nora S. Newcombe, Jason Chein   +2 more
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Impact of Empathy and Perspective-Taking on Medical Student Satisfaction and Performance: A Meta-Ethnography and Proposed Bow-Tie Model

International Medical Education
Background: Empathy and perspective-taking are, respectively, associated with improved healthcare and educational outcomes. However, numerous studies show that medical students are experiencing a significant decline in self-reported empathy.
Chao Tian Tang, Lucas Jun Hao Lim, Haoming Tang, Gaytri Gupta, Isabelle Chiao Han Sung, Chaoyan Dong   +5 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Let’s Talk About Race: The Use of Virtual Reality in Improving Higher Education Students’ Understanding of Privilege

Teaching & Learning Inquiry: The ISSOTL Journal
The prevalence of virtual reality (VR) is growing in many educational spaces. Yet while explored extensively in medical science research, there is a need for more studies on VR in educational and social science research.
Shawnee Hardware, Christine Quiogue, Melissa Gallo, Michael Avis   +3 more
doaj   +1 more source