Results 101 to 110 of about 1,196,383 (294)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Robust Object Detection Under Smooth Perturbations in Precision Agriculture

AgriEngineering
Machine learning algorithms are increasingly used to enhance agricultural productivity cost-effectively. A critical task in precision agriculture is locating a plant’s root collar.
Nesma Talaat Abbas Mahmoud, Indrek Virro, A. G. M. Zaman, Tormi Lillerand, Wai Tik Chan, Olga Liivapuu, Kallol Roy, Jüri Olt   +7 more
doaj   +1 more source

A note on generalization of Zermelo navigation problem on Riemannian manifolds with strong perturbation

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2017
We generalize the Zermelo navigation on Riemannian manifolds (M; h), admitting a space dependence of a ship's speed 0 < |u(x)|h ≤ 1 in the presence of a perturbation W̃ determined by a strong (critical) velocity vector field satisfying |W̃ (x)|h = |u(x ...
Kopacz Piotr
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ÉTUDE DES VARIATIONS DES COMMUNAUTÉS VÉGÉTALES AQUATIQUES SOUS L'EFFET DE PERTURBATIONS ANTHROPIQUES EN RIVIÈRE RÉGULÉE.

Knowledge and Management of Aquatic Ecosystems, 2001
Les macrophytes de la Rance sont étudiés selon le protocole d'échantillonnage « Milieu Et Végétation aquatique fixée (MEV) » des Agences de l'Eau. Cette rivière armoricaine subit des pollutions industrielles, agricoles et perturbations hydrauliques ...
BERNEZ I., DANIEL H., HAURY J.
doaj   +1 more source

Perturbation of convex risk minimization and its application in differential private learning algorithms

Journal of Inequalities and Applications, 2017
Convex risk minimization is a commonly used setting in learning theory. In this paper, we firstly give a perturbation analysis for such algorithms, and then we apply this result to differential private learning algorithms.
Weilin Nie, Cheng Wang
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On the Connection Between the ABS Perturbation Methodology and Differential Privacy

The Journal of Privacy and Confidentiality
This paper explores analytical connections between the perturbation methodology of the Australian Bureau of Statistics (ABS) and the differential privacy (DP) framework. We consider a single static counting query function and find the analytical form of
Chien-Hung Chien, Parastoo Sadeghi
doaj   +1 more source