Results 101 to 110 of about 753,055 (286)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Small-scale Dynamo with Nonzero Correlation Time
The Astrophysical JournalThe small-scale dynamo is typically studied by assuming that the correlation time of the velocity field is zero. Some authors have used a smooth renovating flow model to study how the properties of the dynamo are affected by the correlation time being ...
Kishore Gopalakrishnan, Nishant K Singh
doaj +1 more source
Spectral Norm Regularization for Improving the Generalizability of Deep Learning
, 2017 We investigate the generalizability of deep learning based on the sensitivity to input perturbation. We hypothesize that the high sensitivity to the perturbation of data degrades the performance on it.
Yoshida, Yuichi, Miyato, Takeru
core
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Secular Dynamics of Compact Three-planet Systems
The Astrophysical JournalThe secular Laplace–Lagrange orbital solution, decomposing eccentricities into a set of uniformly precessing eigenmodes, is a classical result that is typically solved numerically.
Qing Yang, Daniel Tamayo
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Intelligent perturbation algorithms for space scheduling optimization [PDF]
Intelligent perturbation algorithms for space scheduling optimization are presented in the form of the viewgraphs. The following subject areas are covered: optimization of planning, scheduling, and manifesting; searching a discrete configuration space ...
Kurtzman, Clifford R.
core +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
A hybrid perturbation-Galerkin technique for partial differential equations [PDF]
A two-step hybrid perturbation-Galerkin technique for improving the usefulness of perturbation solutions to partial differential equations which contain a parameter is presented and discussed.
Anderson, Carl M., Geer, James F.
core +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source