Results 51 to 60 of about 47,542 (262)
REGULARIZATION OF PONTRYAGIN MAXIMUM PRINCIPLE IN OPTIMAL CONTROL OF DISTRIBUTED SYSTEMS
Ural Mathematical Journal, 2016 This article is devoted to studying dual regularization method applied to parametric convex optimal control problem of controlled third boundary–value problem for parabolic equation with boundary control and with equality and inequality pointwise state ...
Mikhail I. Sumin
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Testing the Cosmological Principle in an Axisymmetric Metric from Ia SNe and CMB
UniverseWe investigate the possibility of testing the Cosmological Principle within a specific axisymmetric metric. Starting from the Einstein field equations, we derive a perturbed form of the Friedmann equation based on this metric and obtain a generalized ...
Shuangnan Chen +3 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
A note on a continuation principle for compact perturbations of the identity
Differential and Integral Equations, 1992 This article deals with the equation \(F(x,\lambda)=0\) where \(F(x,\lambda)=x-k(x,\lambda)\), \((x,\lambda)\in {\mathcal O}\subseteq X\times\mathbb{R}^ n\), \(X\) is a real Banach space, \(k(x,\lambda)\) is continuous on \({\mathcal O}\) and compact on the open sets \({\mathcal O}(\varepsilon)\), \(\bigcup_ \varepsilon {\mathcal O}(\varepsilon ...
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The Quantum Action Principle in the Framework of Causal Perturbation Theory [PDF]
, 2009 20 pages. Contribution to the Conference on 'Recent Developments in Quantum Field Theory' held from July 20 to July 22, 2007 at the Max Planck Institute for Mathematics in the Sciences, Leipzig ...
Brennecke, Ferdinand, Duetsch, Michael
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
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Efficiency of reversible reaction: a graphical approach
Chemistry Teacher International, 2022 We describe simple, quantitative, graphical approach to solve chemical equilibrium problems and quantify how far the reversible reaction advances upon reaching equilibrium state at a given temperature.
Novak Igor
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
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