Results 61 to 70 of about 2,121,946 (336)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Numerical study of the applicability of the Saint-Venant principle

MATEC Web of Conferences, 2017
The limits of the applicability of the Saint-Venant principle are investigated while using the LIRA-CAD app. A large number of bars loaded at the end with different loads are considered.
Paushkin Alexander, Saiyan Sergey
doaj   +1 more source

REGULARIZATION OF PONTRYAGIN MAXIMUM PRINCIPLE IN OPTIMAL CONTROL OF DISTRIBUTED SYSTEMS

Ural Mathematical Journal, 2016
This article is devoted to studying dual regularization method applied to parametric convex optimal control problem of controlled third boundary–value problem for parabolic equation with boundary control and with equality and inequality pointwise state ...
Mikhail I. Sumin
doaj   +1 more source

A recovery principle provides insight into auxin pattern control in the Arabidopsis root [PDF]

, 2017
Regulated auxin patterning provides a key mechanism for controlling root growth and development. We have developed a data-driven mechanistic model using realistic root geometry and formulated a principle to theoretically investigate quantitative auxin ...
Simon Moore, Keith Lindsey, Moore, S., Junli Liu, Liu, J., Xiaoxian Zhang, Zhang, X., Lindsey, K.   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Testing the Cosmological Principle in an Axisymmetric Metric from Ia SNe and CMB

Universe
We investigate the possibility of testing the Cosmological Principle within a specific axisymmetric metric. Starting from the Einstein field equations, we derive a perturbed form of the Friedmann equation based on this metric and obtain a generalized ...
Shuangnan Chen, Xiaofeng Yang, Yunliang Ren, Sufen Guo   +3 more
doaj   +1 more source

Exciton-plasmon coupling interactions: from principle to applications

, 2017
The interaction of exciton-plasmon coupling and the conversion of exciton-plasmon-photon have been widely investigated experimentally and theoretically.
En Cao, Weihua Lin, Mengtao Sun, W. Liang, Yuzhi Song   +4 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A note on a continuation principle for compact perturbations of the identity

Differential and Integral Equations, 1992
This article deals with the equation \(F(x,\lambda)=0\) where \(F(x,\lambda)=x-k(x,\lambda)\), \((x,\lambda)\in {\mathcal O}\subseteq X\times\mathbb{R}^ n\), \(X\) is a real Banach space, \(k(x,\lambda)\) is continuous on \({\mathcal O}\) and compact on the open sets \({\mathcal O}(\varepsilon)\), \(\bigcup_ \varepsilon {\mathcal O}(\varepsilon ...
openaire   +4 more sources