Results 41 to 50 of about 66,767 (293)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Coordinate-independent singular perturbation reduction for systems with three time scales
, 2019 On the basis of recent work by Cardin and Teixeira on ordinary differential equations with more than two time scales, we devise a coordinate-independent reduction for systems with three time scales; thus no a priori separation of variables into fast ...
Kruff, Niclas, Walcher, Sebastian
core +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Effective Equations of Motion for Quantum Systems
, 2005 In many situations, one can approximate the behavior of a quantum system, i.e. a wave function subject to a partial differential equation, by effective classical equations which are ordinary differential equations.
AURELIANO SKIRZEWSKI +4 more
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Singularly perturbed ordinary differential equations
Journal of Mathematical Analysis and Applications, 1992 Consider abstract nonlinear equations of the form (*) \(Lu+\varepsilon F(u,v)=0\), \(S(v)+\varepsilon V(u,v)=0\) where \(L\) is linear, \(\varepsilon\) is a small parameter. By using the coincidence degree the author derives conditions on the operators such that (*) has a solution.
openaire +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Generalized nonuniform dichotomies and local stable manifolds
, 2013 We establish the existence of local stable manifolds for semiflows generated by nonlinear perturbations of nonautonomous ordinary linear differential equations in Banach spaces, assuming the existence of a general type of nonuniform dichotomy for the ...
AJG Bento +10 more
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Newtonian Analysis of Gravitational Waves from Naked Singularity [PDF]
, 2000 Spherical dust collapse generally forms a shell focusing naked singularity at the symmetric center. This naked singularity is massless. Further the Newtonian gravitational potential and speed of the dust fluid elements are everywhere much smaller than ...
A. Ori +34 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source