Results 61 to 70 of about 6,274 (271)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Continuity, Discontinuity and Dynamics in Mathematics & Economics - Reconsidering Rosser's Visions [PDF]

Barkley Rosser has been a pioneer in arguing the case for the mathematics of discontinuity, broadly conceived, to be placed at the foundations of modelling economic dynamics. In this paper we reconsider this vision from the broad perspective of a variety
Stefano Zambelli, K. Vela Velupillai
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Efficient method for solving highly oscillatory ordinary differential equations with applications to physical systems

Physical Review Research, 2020
We present a numerical routine (oscode) with a C++ and Python interface for the efficient solution of one-dimensional, second-order, ordinary differential equations with rapidly oscillating solutions.
F. J. Agocs, W. J. Handley, A. N. Lasenby, M. P. Hobson   +3 more
doaj   +1 more source

Singular perturbed problems in ordinary differential equations

Journal of Mathematical Analysis and Applications, 1992
The author uses his recent version of the generalized implicit theorem of Nash and Moser to solve perturbed periodic problems for equations like (1) \(u'+e\cdot f(u,u',u'',u''',t)=0\), in which perturbations contain two order higher derivatives than unperturbed equations.
openaire   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

MHD Boundary Layer Flow near Stagnation Point of Linear Stretching Sheet with Variable Thermal Conductivity via He’s Homotopy Perturbation Method

Journal of Applied Fluid Mechanics, 2015
MHD boundary layer flow near stagnation point of linear stretching sheet with variable thermal conductivity are solved using He’s Homotopy Perturbation Method (HPM), which is one of the semi-exact method. Similarity transformation has been used to reduce
JHANKAL KUMAR ANUJ
doaj  

A new stochastic compartmental epidemic model driven by a multidimensional stochastic differential equation under a voluntary and imperfect vaccination strategy

Kuwait Journal of Science
This work introduces a novel compartmental epidemic model that integrates both deterministic and stochastic components to capture the dynamics of disease transmission under a voluntary and imperfect vaccination strategy.
Benasquar Mohammed, Aissa Sghir, Dr. Said El Idrissi   +2 more
doaj   +1 more source

Model selection in the reconstruction of regulatory networks from time-series data

BMC Research Notes, 2009
Background A widely used approach to reconstruct regulatory networks from time-series data is based on the first-order, linear ordinary differential equations.
Barillot Emmanuel, Novikov Eugene
doaj   +1 more source