Results 51 to 60 of about 66,767 (293)

On Robust Stability of Differential-Algebraic Equations with Structured Uncertainty

Известия Иркутского государственного университета: Серия "Математика", 2018
We consider a linear time-invariant system of differential-algebraic equations (DAE), which can be written as a system of ordinary differential equations with non-invertible coefficients matrices.
A. Kononov
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Bifurcation of multi-bump homoclinics in systems with normal and slow variables

Electronic Journal of Differential Equations, 2000
Bifurcation of multi-bump homoclinics is studied for a pair of ordinary differential equations with periodic perturbations when the first unperturbed equation has a manifold of homoclinic solutions and the second unperturbed equation is vanishing.
Michal Feckan
doaj  

Applications of the Kosambi–Cartan–Chern Theory to Hamiltonian Systems on a Cotangent Bundle: Linking Geometric Quantities to the Self-Similar Motions of Three Point Vortices

Mathematics
This study presents a differential geometric framework for Hamiltonian systems expressed in terms of first-order differential equations. For systems governed by second-order ordinary differential equations on tangent bundles, such as Euler–Lagrange ...
Yuma Hirakui, Takahiro Yajima
doaj   +1 more source

Stability of solutions for systems of delayed parabolic equations

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2023
Background. The study is devoted to the analysis of stability in the sense Lyapunov steady state solutions for systems of linear parabolic equations with coefficients depending on time, and with delays depending on time.
Il'ya V. Boykov
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The stability of Cohen–Grossberg neural networks with time dependent delays

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2023
Background. The study is devoted to the analysis of stability in the sense Lyapunov Cohen-Grossberg neural networks with time-dependent delays. To do this, we study the stability of the steady-state solutions of systems of linear differential equations ...
Il'ya V. Boykov, Vladimir A. Rudnev, Alla I. Boykova   +2 more
doaj   +1 more source

Robust Controllability of Non-Stationary Differential-Algebraic Equations [PDF]

Известия Иркутского государственного университета: Серия "Математика", 2018
We consider linear time-varying system of first order ordinary differential equations with identically degenerate matrix of the derivative of the unknown function. Such systems are called differential-algebraic equations (DAE).
P.S. Petrenko
doaj   +1 more source

Lectures on Linear Stability of Rotating Black Holes

, 2019
These lecture notes are concerned with linear stability of the non-extreme Kerr geometry under perturbations of general spin. After a brief review of the Kerr black hole and its symmetries, we describe these symmetries by Killing fields and work out the ...
AA Starobinsky, B Carter, BF Whiting, BF Whiting, CW Misner, F Finster, JL Friedman, PR Chernoff, R Adler, R Güven, R Penrose, RM Wald, T Regge, V Alfaro de, WH Press, YB Zel’dovich   +15 more
core   +1 more source