Results 91 to 100 of about 645,718 (276)

Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model

open access: yesBMC Infectious Diseases, 2017
Background Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries.
Hyo Jin Kwon   +7 more
doaj   +1 more source

Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection

open access: yesBMC Infectious Diseases, 2021
Background The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly
Wenwen Jiang   +14 more
doaj   +1 more source

Protocol for a feasibility and acceptability study for UK general population paediatric type 1 diabetes screening—the EarLy Surveillance for Autoimmune diabetes (ELSA) study

open access: yesDiabetic Medicine, Volume 42, Issue 5, May 2025.
Abstract Aim The EarLy Surveillance for Autoimmune (ELSA) study aims to explore the feasibility and acceptability of UK paediatric general population screening for type 1 diabetes. Methods We aim to screen 20,000 children aged 3–13 years for islet‐specific autoantibodies through dried blood spot sample collection at home, hospital or community settings.
Lauren M. Quinn   +20 more
wiley   +1 more source

Epidemiological consequences of an ineffective Bordetella pertussis vaccine [PDF]

open access: yesarXiv, 2014
The recent increase in Bordetella pertussis incidence (whooping cough) presents a challenge to global health. Recent studies have called into question the effectiveness of acellular B. pertussis vaccination in reducing transmission. Here we examine the epidemiological consequences of an ineffective B. pertussis vaccine.
arxiv  

Analysis of COVID-19 in India using vaccine epidemic model incorporating vaccine effectiveness and herd immunity [PDF]

open access: yesarXiv, 2022
COVID-19 will be a continuous threat to human population despite having a few vaccines at hand until we reach the endemic state through natural herd immunity and total immunization through universal vaccination. However, the vaccine acts as a practical tool for reducing the massive public health problem and the emerging economic consequences that the ...
arxiv  

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

open access: yesThe FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw   +2 more
wiley   +1 more source

Mathematical Model of Vaccine Noncompliance [PDF]

open access: yes, 2016
Vaccine scares can prevent individuals from complying with a vaccination program. When compliance is high, the critical vaccination proportion is close to being met, and herd immunity occurs, bringing the disease incidence to extremely low levels.
Bauer, Jordan, Capaldi, Alex
core   +2 more sources

Validation and implementation of a diagnostic algorithm for DNA Detection of Bordetella pertussis, B. parapertussis, and B-holmesii in a Pediatric Referral Hospital in Barcelona, Spain [PDF]

open access: yes, 2019
This study aimed to validate a comprehensive diagnostic protocolbased on real-time PCR for the rapid detection and identification ofBordetella per-tussis,Bordetella parapertussis, andBordetella holmesii, as well as its implementationin the diagnostic ...
Acosta Argueta, Lesly María   +5 more
core   +2 more sources

Simultaneous coinfection with influenza virus and an arbovirus impedes influenza‐specific but not Semliki Forest virus–specific responses

open access: yesImmunology &Cell Biology, Volume 103, Issue 4, Page 383-400, April 2025.
In this study, we found that simultaneous infection with neurotropic Semliki Forest virus (SFV) and respiratory influenza A virus (IAV) does not lead to exacerbated or attenuated disease compared with the single virus infection control groups. However, coinfection impairs IAV immunity demonstrated by enhanced IAV replication in the lungs and decreased ...
Isabelle Jia‐Hui Foo   +5 more
wiley   +1 more source

Spatio-temporal modeling of co-dynamics of smallpox, measles and pertussis in pre-healthcare Finland [PDF]

open access: yesarXiv, 2023
Infections are known to interact as previous infections may have an effect on risk of succumbing to a new infection. The co-dynamics can be mediated by immunosuppression or -modulation, shared environmental or climatic drivers, or competition for susceptible hosts.
arxiv  

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