Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection [PDF]
mSpherePertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová +6 more
doaj +2 more sources
Acellular Pertussis Vaccine Components: Today and Tomorrow [PDF]
Vaccines (Basel), 2020 Pertussis is a highly communicable acute respiratory infection caused by Bordetella pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks occur cyclically worldwide and effective vaccination strategies are needed
K. Dewan +3 more
semanticscholar +2 more sources
Modeling the long term dynamics of pre-vaccination pertussis [PDF]
Journal of the Royal Society Interface 9, 2959-2970 (2012), 2011 The dynamics of strongly immunizing childhood infections is still not well understood. Although reports of successful modeling of several incidence data records can be found in the literature, the key determinants of the observed temporal patterns have not been clearly identified.
Ana Nunes +4 more
arxiv +3 more sources
Infection-acquired versus vaccine-acquired immunity in an SIRWS model [PDF]
arXiv, 2017 Despite high vaccine coverage, pertussis has re-emerged as a public health concern in many countries. One hypothesis posed for re-emergence is the waning of immunity. In some disease systems, the process of waning immunity can be non-linear, involving a complex relationship between the duration of immunity and subsequent boosting of immunity through ...
Campbell, Patricia T +4 more
arxiv +5 more sources
Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture [PDF]
Frontiers in Immunology, 2021 Outer membrane vesicles (OMV) derived from Bordetella pertussis—the etiologic agent of the resurgent disease called pertussis—are safe and effective in preventing bacterial colonization in the lungs of immunized mice.
Francisco Carriquiriborde +9 more
doaj +2 more sources
Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model [PDF]
Frontiers in Immunology, 2022 Pertussis, caused by the gram-negative bacterium Bordetella pertussis, is a highly contagious respiratory disease. Intranasal vaccination is an ideal strategy to prevent pertussis, as the nasal mucosa represents the first-line barrier to B.
Wenwen Jiang +9 more
doaj +2 more sources
Assessment of Pertussis Vaccine Protective Effectiveness in Children in the Amhara Regional State, Ethiopia [PDF]
International Journal of Microbiology, 2020 Background. Bordetella pertussis is a human pathogen which causes pertussis, or whooping cough. The diphtheria-tetanus-pertussis immunization has significantly reduced the morbidity and mortality of pertussis globally.
Solomon Taye +3 more
doaj +2 more sources
Isolate-Based Surveillance of Bordetella pertussis, Austria, 2018–2020
Emerging Infectious Diseases, 2021 Pertussis is a vaccine-preventable disease, and its recent resurgence might be attributable to the emergence of strains that differ genetically from the vaccine strain.
Adriana Cabal +14 more
doaj +1 more source
Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans.
Journal of Clinical Investigation, 2020 BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1. METHODS We
Ang Lin +13 more
semanticscholar +1 more source
An infant who suffered seizures many times after pentavalent vaccination: A case report
İstanbul Kuzey Klinikleri, 2020 Although rare, serious adverse effects may be seen after vaccination. Especially, the whole-cell pertussis vaccine has been held responsible for neurological side effects, as the most important problem in vaccination.
Meryem Erat Nergiz +4 more
doaj +1 more source