Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy. [PDF]
Med Princ Pract, 2022 Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis. Although most cases occur in developing countries, it is considered endemic globally.
Alghounaim M +4 more
europepmc +2 more sources
Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis. [PDF]
Emerg Infect Dis, 2021 Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Ma L, Caulfield A, Dewan KK, Harvill ET.
europepmc +2 more sources
Evaluating the Relationship Between the Introduction of the Acellular Pertussis Vaccine and Whooping Cough Resurgence in the United States [PDF]
VaccinesBackground/Objectives: The whole cell pertussis vaccine was introduced in the United States in the 1940s and switched to the acellular pertussis vaccine partially in 1992 and completely in 1997. This study examines the relationship between the resurgence
Jeegan Parikh +2 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated ...
María Eugenia Zurita +7 more
doaj +2 more sources
Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection [PDF]
mSpherePertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová +6 more
doaj +2 more sources
Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice
Vaccines, 2020 Bordetella pertussis whole-cell vaccines (wP) caused a spectacular drop of global pertussis incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis has resurged in developed countries within 7 to 12 years of the ...
Jana Holubová +7 more
doaj +2 more sources
Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture [PDF]
Frontiers in Immunology, 2021 Outer membrane vesicles (OMV) derived from Bordetella pertussis—the etiologic agent of the resurgent disease called pertussis—are safe and effective in preventing bacterial colonization in the lungs of immunized mice.
Francisco Carriquiriborde +9 more
doaj +2 more sources
Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model [PDF]
Frontiers in Immunology, 2022 Pertussis, caused by the gram-negative bacterium Bordetella pertussis, is a highly contagious respiratory disease. Intranasal vaccination is an ideal strategy to prevent pertussis, as the nasal mucosa represents the first-line barrier to B.
Wenwen Jiang +9 more
doaj +2 more sources
Frontiers in Immunology, 2023 Pertussis is a severe human respiratory tract infectious disease caused by Bordetella pertussis that primarily affects infants and young children.
Jingjing Gao +6 more
doaj +1 more source
Frontiers in Immunology, 2023 Despite the high coverage of pertussis vaccines in high-income countries, pertussis resurgence has been reported in recent years, and has stimulated interest in the effects of vaccines and vaccination strategies. Immunoglobulin G (IgG) antibodies against
Zhiying Yin +8 more
doaj +1 more source